Clinical study of rhubarb combined with probiotics to improve cytokine storm in patients with ARDS

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ITMCTR

Registry ID

ITMCTR2100004252

Enrollment

Unknown

Registered

2020-10-14

Start date

2020-11-13

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome

Interventions

Rhubarb Treatment Group:Rhubarb Enema

Control group:Nil

Rhubarb + Probiotics Treatment Group:Rhubarb enema combined with probiotic treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18-70 years; 2. Patients admitted to ICU; 3. The diagnosis meets the ARDS criteria and the mechanical ventilation time is greater than or equal to 48 hours; 4. Patients or their family members sign informed consent, cooperate with the investigation and comply with the patients.

Exclusion criteria

Exclusion criteria: 1. Patients who died within 72 hours after tracheal intubation; 2. Pregnant women; 3. Patients with immunodeficiency/injury; 4. Patients with gastrointestinal obstruction or bleeding; 5. Diabetic.

Design outcomes

Primary

Measure	Time frame
Inflammatory factor levels;	—

Secondary

Measure	Time frame
Lymphocyte count;Intestinal flora composition;28-day mortality;Short-chain fatty acid content in serum and stool;Neutrophil count;temperature;Procalcitonin;White blood cell count;	—

Countries

China

Contacts

Public ContactYin Jiangtao

Affiliated Hospital of Jiangsu University

doctoryjt2438@163.com+86 13952943135

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026