Premature Ovarian Insufficiency
Conditions
Interventions
POI Acupuncture Group:IVF-ET following treatment with the Circular Motion Acupuncture Method based on the "One Source, Three Branches" Theory
POI Non-acupuncture Group:Routine IVF-ET Treatment
Non-female-factor Control Group:Routine IVF-ET Treatment
Sponsors
Hubei Maternity and Child Health Care Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1)Women scheduled to undergo in vitro fertilization and embryo transfer (IVF-ET) procedures and routine oocyte retrieval; (2)Residual follicular fluid samples that would otherwise be discarded after routine clinical processing can be obtained during oocyte retrieval; (3)Participants in the POI intervention group and POI control group meet the diagnostic criteria for Premature Ovarian Insufficiency (POI) or are assessed by reproductive specialists as having diminished ovarian function; (4)Participants in the non-ovarian-factor control group undergo assisted reproductive treatment due to non-ovarian factors, such as male-factor infertility or tubal-factor infertility. Female participants have normal ovarian reserve function and no confirmed POI or other reproductive endocrine disorders that may significantly affect follicular fluid test results; (5)Able to understand the study procedures, voluntarily participate in the study, and provide written informed consent.
Exclusion criteria
Exclusion criteria: (1) Participants with severe diseases involving major organs or systems, including the cardiovascular, hepatic, renal, or hematopoietic systems; (2) Participants with malignant tumors, severe infections, or other diseases that, in the opinion of the investigators, may significantly affect the results of follicular fluid analysis; (3) Participants whose follicular fluid samples are obviously blood-stained, contaminated, or insufficient in volume to meet the testing requirements; (4) Participants with incomplete clinical data or those considered unsuitable for inclusion by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transcriptomic Characteristics of Follicular Fluid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Differentially Expressed Genes;Differential Metabolites;Differentially Expressed Proteins; | — |
Countries
China
Contacts
Public ContactGuo jianfang
Hubei Maternity and Child Health Care Hospital
Outcome results
None listed