Gastroesophageal Reflux Disease
Conditions
Interventions
Experimental Group:Acupuncture intervention oral taking proton pump inhibitors
Control Group:Shame acupuncture intervention with oral taking proton pump inhibitors
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age = 18 and = 75 years; No gender perference; (2) Meets the diagnostic criteria for gastroesophageal reflux disease (GERD): presence of typical heartburn and/or reflux symptoms lasting = 3 months; Gastroesophageal Reflux Disease Questionnaire (GERDQ) score = 8. Or, within the past year, have been diagnosed with reflux esophagitis (Los Angeles [LA] grade A or higher) via upper gastrointestinal endoscopy, or have been confirmed to have pathological reflux via 24-hour esophageal pH-impedance monitoring; (3) Be mentally alert and lucid, able to correctly understand the questionnaire assessment, and capable of completing the questionnaire independently; (4) Understand and agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Gastroscopy reveals Barrett's esophagus, hiatal hernia, esophageal cancer, or severe esophageal erosion (LA grade C/D); (2) History of esophageal or gastric surgery; (3) At the time of enrollment, patients with relatively severe underlying diseases of the cardiovascular, cerebrovascular, hepatic, renal, endocrine, hematological, or neuropsychiatric systems, or a tendency to bleed; (4) Pregnant or breastfeeding women, or women currently planning to become pregnant; (5) Patients currently participating in other clinical trials involving drugs or medical devices; (6) Patients with an allergy to acupuncture or who experience psychological anxiety that prevents them from cooperating with this treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in gastroesophageal reflux disease questionnaire scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in gastroesophageal reflux disease-quality of life questionnaire scores;changes in visceral sensitivity index scores;Neuroinflammation markers (SP, CGRP, IL-6, TNF-a, BDNF); | — |
Countries
China
Contacts
Public ContactLI Jing, HE Jing
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed