Chronic gastritis
Conditions
Interventions
Intervention group:Quadruple therapy + Jiuwei Xiexin Decoction. Quadruple therapy: proton pump inhibitor (omeprazole 30 mg once daily) + bismuth agent (bismuth potassium citrate 0.24 g four times dail
Control group:Quadruple therapy: proton pump inhibitor (omeprazole 30 mg once daily) + bismuth agent (bismuth potassium citrate 0.24 g four times daily) + two antibiotics (amoxicillin 0.5 g twice dail
Sponsors
Institute of Clinical Basic Medicine, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Meet the Western diagnostic criteria for chronic gastritis and the Traditional Chinese Medicine (TCM) diagnostic criteria for spleen-stomach damp-heat syndrome; 2.Aged 18 to 75 years; 3. Current positive for Helicobacter pylori (Hp); 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of peptic ulcer or upper gastrointestinal bleeding; 2. High-grade intraepithelial neoplasia or malignant transformation of the gastric mucosa; 3. Requirement for long-term use of non-steroidal anti-inflammatory drugs (NSAIDs); 4. Pregnant or breastfeeding women; 5. Use of anticholinergic agents, prokinetics, or other medications that may affect gastrointestinal function within the past 2 weeks; 6. Presence of severe organic diseases (e.g., heart, brain, liver, kidney, lung, or hematologic system disorders); 7. Diagnosed with mental illness or unable to actively cooperate with the trial procedures; 8. Currently participating in other drug clinical trials; 9. Any condition that, in the investigator's judgment, makes the participant unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori (Hp) eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Response rate of improvement in total target symptom score;Response rate of improvement for individual symptoms;Time to symptom resolution;TCM syndrome efficacy evaluation;Gastric function tests;Patient quality of life assessment; | — |
Countries
China
Contacts
Public Contactyinxiuping
Institute of Clinical Basic Medicine, China Academy of Chinese Medical Sciences
Outcome results
None listed