aging
Conditions
Interventions
Experimental group:Take the solid beverage once daily, one sachet each time, dissolved in 550 mL warm water for oral administration.
Control group:Take placebo once daily, one sachet each time, dissolved in 550 mL warm water for oral administration.
Sponsors
School of Public Health,Zhengzhou University
Eligibility
Sex/Gender
Female
Age
40 Years to 55 Years
Inclusion criteria
Inclusion criteria: (1) Healthy Chinese women aged 40–55 years who are capable of independent activity; (2) Classified as "pre-frail" according to the Fried Frailty Scale; (3) Diagnosed via Traditional Chinese Medicine (TCM) as exhibiting symptoms of "deficiency of Essence, Qi, and Blood"; (4) Able to read Chinese, accurately understand the trial procedures, and voluntarily participate in the study by signing the informed consent form; (5) Able to cooperate with and attend scheduled follow-up visits, promptly report any changes in their health status or regarding the study food, report any adverse reactions, and adhere to the study requirements and schedule.
Exclusion criteria
Exclusion criteria: (1) Those complicated with severe diseases of vital organs including the heart, liver, lung and kidney, hematological diseases, neoplastic diseases, etc.(2) Subjects with severe mental illness who cannot control their own behaviors and are unable to cooperate with the trial.(3) Those with chronic diseases that have not been effectively controlled.(4) Individuals with alcohol or drug abuse.(5) Those who have taken products related to the tested function within the recent one month (e.g., antioxidants, immunomodulatory and tonic agents, mitochondrial activators, etc.), which may interfere with the judgment of trial results.(6) Those with a past medical history of gastrointestinal surgery or gastrointestinal diseases (e.g., history of gastric or duodenal surgery, inflammatory bowel disease, malabsorption syndrome, etc.).(7) Those with allergic constitution or potential allergy to the ingredients of the test product.(8) Women who are pregnant, planning to become pregnant, or breastfeeding.(9) Those who have participated in or are participating in other clinical trials within the recent three months.(10) Those deemed unsuitable for participation in this trial or prone to loss to follow-up by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA methylation level;biological age;telomere length;mitochondrial mtDNA copy number; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCM syndrome score of deficiency of essence, qi and blood;Pittsburgh Sleep Quality Index;Montreal Cognitive Assessment;menstrual status;Estrogen level;modified Kupperman Index; | — |
Countries
China
Contacts
Public ContactBo Yacong
School of Public Health,Zhengzhou University
Outcome results
None listed