Sepsis Myocardial Injury
Conditions
Interventions
Experimental Group:In addition to the routine treatment recommended by the SSC guidelines, Tongfu Yiqi Decoction (Rheum palmatum 9g, Citrus aurantium 6g, Panax ginseng 9g, Astragalus membranaceus 20g,
Control Group:Conventional treatment
Sponsors
Jiangsu Province Integrated Chinese and Western Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Sign written informed consent to participate in the trial; be male or female, aged 18 years or older and less than 90 years old on the day of signing informed consent; patients with atrial fibrillation who developed new-onset atrial fibrillation confirmed by electrocardiogram during hospitalization, with no prior history of atrial fibrillation; patients with sepsis-associated myocardial injury receiving standard drug therapy for improved prognosis (diagnosed based on cardiac dysfunction or hemodynamic abnormalities in sepsis patients, combined with echocardiographic abnormalities and elevated myocardial injury biomarkers; sepsis: definite or suspected evidence of infection + SOFA score = 2 points; myocardial injury: elevated troponin levels exceeding the normal reference upper limit (99th percentile), cTnT > 0.01 ng/mL); patients may have outcomes such as new-onset atrial fibrillation, cardiogenic shock, days on endotracheal intubation, and mortality as prognostic indicators.
Exclusion criteria
Exclusion criteria: Had a clear history of atrial fibrillation before admission; hospitalization duration was too short (e.g., less than 24 hours); had chest trauma or received heart-related treatment (e.g., cardiopulmonary resuscitation, electrical cardioversion, or electrical defibrillation) within 7 days prior to this treatment; significant missing of key clinical data; pregnant or breastfeeding women; allergic constitution or patients allergic to traditional Chinese medicine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of NOAF; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Function;Myocardial injury biomarkers;Inflammation and Intestinal Barrier Function;Disease severity;Disease-related protein;7-day mortality rate;28-day mortality rate;ICU hospital stay;Mechanical Ventilation Duration; | — |
Countries
China
Contacts
Public ContactHuang Dan
Jiangsu Province Integrated Chinese and Western Medicine Hospital
Outcome results
None listed