Severe depressive disorder
Conditions
Interventions
Acupuncture group:Acupuncture
Sham acupuncture group:Sham acupuncture
Sponsors
Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: a. Age: 18-65 years old, first-time or primary patients. b. Meet the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). c. Total score of HAMD-17 scale at enrollment >24 points. d. Nightmare Severity Index >10 points; e. Stable disease control, with no changes in treatment regimen in the month prior to enrollment; f. Signed informed consent and volunteered to participate.
Exclusion criteria
Exclusion criteria: a. Individuals with severe suicidal tendencies. b. Depressive episodes secondary to other mental illnesses or physical diseases. c. Individuals with severe comorbidities in other systems, as well as those with heart, liver, and kidney dysfunction. d. Pregnant or breastfeeding women, or those planning to become pregnant. e. Known alcoholics or drug addicts. f. Patients with glaucoma and epilepsy. g. Individuals who are unsupervised or unable to complete clinical trials. h. Individuals with implanted metal devices in the brain (excluding titanium), artificial cochlear implants, pulse generators, cardiac pacemakers, and other internal metal implants. i. Individuals with increased risk of inducing epilepsy: those with a history of epilepsy, sleep deprivation, or alcohol dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nightmare Severity Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale (17-item);Insomnia Severity Index;Beck Suicide Ideation Scale;Pittsburgh Sleep Quality Index;Polysomnography; | — |
Countries
China
Contacts
Public ContactXu Mindong
Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed