Paroxysmal Atrial Fibrillation
Conditions
Interventions
Exposure group:Receiving TCM treatment
Non-exposure group:Not receiving TCM treatment
Sponsors
Jiangsu Province Hospital on Integration of Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: • Age 18-80, any gender • Meets Western diagnostic criteria for paroxysmal AF • Meets any TCM syndrome differentiation type of "Rapid Pulse Syndrome" • Additional criteria for PCT subgroup: Undergone catheter ablation (radiofrequency/cryoballoon/pulsed-field) with successful pulmonary vein isolation.
Exclusion criteria
Exclusion criteria: • Persistent/permanent AF • Severe organic heart disease (e.g., significant valvular disease requiring surgery, uncorrected congenital heart disease, hypertrophic obstructive cardiomyopathy) • Severe hepatic/renal dysfunction (ALT/AST >3×ULN; eGFR <30 ml/min/1.73m²) • Malignancy with life expectancy <2 years • Pregnancy/lactation • Participation in other interventional trials • Allergy to study TCM components • Psychiatric disorders affecting follow-up • Severe post-ablation complications within 24h (cardiac tamponade, major vascular injury)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AF recurrence rate within 24 weeks; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recurrence frequency per unit time;AF Burden;Time to first AF recurrence (TTFR);Average sinus rhythm conversion time;Non-pharmacological conversion rate;Sinus rhythm maintenance duration (SRMD);Sinus rhythm maintenance rate in efficacy population;Progression to persistent AF rate;TCM syndrome score reduction rate;AFEQT score change from baseline;EQ-5D-5L score change from baseline;EHRA symptom class change;Clinical endpoint event rate; | — |
Countries
China
Contacts
Public ContactWang Xindong
Jiangsu Province Hospital on Integration of Chinese and Western Medicine
Outcome results
None listed