Ischemic Stroke Recovery Phase
Conditions
Interventions
Experimental Group (Sanqi Bingbu Formula Group):Conventional treatment + Sanqi Bingbu Formula decoction: Astragalus 30g, Codonopsis 15g, Cuscuta 15g, Angelica 10g, Chuanxiong 12g, Red Peony 12g, Earth
Control Group:Guideline-recommended conventional treatment: antiplatelet aggregation, lipid-lowering plaque stabilization medications, and standardized management of underlying conditions
Sponsors
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Meet TCM and Western diagnostic criteria for ischemic stroke recovery phase, with Qi Deficiency Syndrome as primary TCM pattern (Qi Deficiency Score =7 points), may include other secondary patterns (2) 3 6 months prior and no significant residual neurological deficits; current episode is recurrent with typical symptoms
Exclusion criteria
Exclusion criteria: (1) Ischemic stroke secondary to special etiologies (tumor, trauma, hematological diseases, vasculitis, vascular malformations) (2) Comorbid severe conditions affecting outcome assessment (malignancy, cardiac dysfunction =NYHA III, respiratory failure, severe infections, severe anemia, uncontrolled thyroid dysfunction) (3) History of allergy/severe adverse reactions to trial drugs/excipients, or severe allergic constitution (4) Severe aphasia/cognitive impairment (MMSE <24) preventing comprehension/cooperation (5) Comorbid excess patterns (Liver Yang Hyperactivity, Phlegm-Heat Bowel Excess, Wind-Fire Disturbance) with pattern scores =7 (6) Recent use (1 month) of Qi-tonifying herbs/patents/health products (e.g., ginseng, astragalus, cordyceps, ginkgo, CoQ10) or Western medications potentially interfering with efficacy assessment (high-dose steroids, sedatives); participation in other clinical trials within 3 months (7) Pregnancy, lactation, or planned pregnancy within 6 months (8) Anticipated non-compliance with prescribed dosage/frequency/duration (9) Other conditions deemed unsuitable by investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Traditional Chinese Medicine Syndrome Score of Qi Deficiency in Stroke; | — |
Secondary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale;Disability Level (Modified Rankin Scale, mRS);Serum Adenosine Triphosphate Concentration;Serum Mitochondrial Respiratory Chain Complex IV;Multidimensional Fatigue Inventory ;Fugl-Meyer Assessment Scale;Activities of Daily Living (Barthel Index);Stroke-Specific Quality of Life Scale ; | — |
Countries
China
Contacts
Public ContactTong Chenguang
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed