subthreshold depression
Conditions
Interventions
Ear Acupoint Seed Pressing Group:Ear Acupoint Seed Pressing Therapy
Waitlist Control group:wait and see
Subcutaneous Needle Group:Subcutaneous needle therapy
Transcutaneous Auricular Vagus Nerve Electrostimulation Treatment Group:Transcutaneous Auricular Vagus Nerve Electrotherapy
Sponsors
Shenzhen City Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
10 Years to 24 Years
Inclusion criteria
Inclusion criteria: 1: Reports of depression, meeting the diagnostic criteria for StD in Western medicine and the diagnostic criteria for depression in traditional Chinese medicine (Yuping); 2: Age between 10-24 years, first episode, no prior use of antidepressants, gender (unrestricted); 3: Hamilton Depression Rating Scale (HAMD-17) score =7 and 14; Young Mania Rating Scale <8 and HCL-32 screening negative; 4: No use of any psychoactive medications or medications affecting cognitive function in the 2 weeks prior to treatment; 5: Educational level of primary school or above; 6: All subjects are right-handed with no clinical contraindications for scanning; 7: Participants voluntarily join and obtain handwritten informed consent from a valid legal guardian.
Exclusion criteria
Exclusion criteria: 1: Clinically diagnosed depressive episodes, or a history of any mental disorder or substance use, or known alcoholism or substance dependence; 2: Severe aphasia, physical disabilities, or any other factors that may affect neuropsychological assessments; or severe somatic diseases or obvious physical examination abnormalities (e.g., electrocardiogram); 3: Suicidal ideation within one month prior to enrollment, regardless of the presence of a specific plan, or patients assessed by the investigator to have a significant risk of suicide; 4: Antidepressant treatment or other therapies or medications within one week prior to the start of the trial; 5: Currently participating in other clinical trials; 6: Surgical scars, skin infections, or cranial defects at the auricular acupoint stimulation sites that may affect treatment; 7: Patients who have experienced vagus nerve stimulation needle fainting or are allergic to ear acupoint pressure bean plaster; 8: Refusal to sign the informed consent form, or inability to cooperate with neuropsychological assessments; 9: Patients with metal implants or claustrophobia, or other contraindications for MRI examinations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficient; | — |
Secondary
| Measure | Time frame |
|---|---|
| 12-month MDD conversion rate;Clinical Global Impressions Scale;T1 Response Rate;Step Therapy Remission Rate; | — |
Countries
China
Contacts
Public ContactQin Xiude
Shenzhen City Traditional Chinese Medicine Hospital
Outcome results
None listed