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Mechanisms Underlying the Effects of Electroacupuncture at the Sanyinjiao and Yinlingquan Points on the Gut-Urinary Tract Microbiome in Patients with Post-Stroke Neurogenic Lower Urinary Tract Dysfunction

Exploring the mechanism of electroacupuncture at Sanyinjiao and Yinlingquan points in modulating gut-urinary tract Microbiota in patients with post-stroke neurogenic lower urinary tract dysfunction based on 16S rDNA sequencing

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026001564
Enrollment
Unknown
Registered
2026-06-23
Start date
2025-12-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurogenic lower urinary tract dysfunction secondary to stroke

Interventions

experimental group:Electroacupuncture: Sanyinjiao and Yinlingquan, 5 times a week, for 2 consecutive weeks
Control group:Sham acupuncture: No meridians or acupoints
5 times per week for 2 consecutive weeks

Sponsors

Chengdu University of Traditional Chinese Med
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 90 Years

Inclusion criteria

Inclusion criteria: (1) Aged between 35 and 90 years (including 35 and 90 years), regardless of gender; (2) Possession of complete clinical and imaging data; (3) Patients experiencing involuntary urination beyond voluntary control or requiring a urinary catheter due to such incontinence, with at least one episode of urinary incontinence per day; (4) Patients requiring a urinary catheter because they are unable to void spontaneously; (5) Patients with stable vital signs, clear consciousness, no significant cognitive or speech impairments, and the ability to cooperate with relevant treatments and examinations as required by the protocol; (6) No recent use of antibiotics or probiotics that significantly affect the microbial flora; (7) No concomitant diseases that significantly affect the microbial flora; (8) Patients who voluntarily understand the study, agree to participate, and sign the Informed Consent Form.

Exclusion criteria

Exclusion criteria: (1) Patients who do not meet the above inclusion criteria; (2) Patients with NLUTD not caused by stroke, or those with a history of urinary dysfunction prior to the onset of stroke; (3) Patients with concomitant organic urinary tract lesions or inflammatory urinary tract reactions; (4) Patients with other serious illnesses or underlying conditions, such as orthostatic hypotension, hepatic or renal insufficiency, severe spinal cord injury, organ diseases and failure (e.g., prostate cancer), or severe infections; (5) Patients with coagulation disorders or a severe tendency to bleed, or those with poor skin sensation or healing capacity; (6) Patients with contraindications to acupuncture or who cannot undergo acupuncture treatment; (7) Patients taking other medications that may interfere with NLUTD treatment; (8) Patients with severe cognitive or psychiatric impairments who are unable to express their intention to urinate; (9) Patients with poor compliance who cannot consistently cooperate to complete treatment and efficacy assessments; (10) Patients with conditions known to significantly alter the structure of the microbiota (e.g., hyperlipidemia, obesity, etc.); (11) Individuals who have recently taken medications, foods, or related health supplements that significantly affect the microbial flora; (12) Individuals who have recently participated in or are currently participating in other clinical trials.

Design outcomes

Primary

MeasureTime frame
Gut-urinary tract microbiota;

Secondary

MeasureTime frame
neurogenic bladder symptom score;

Countries

China

Contacts

Public ContactYuanyuan Zhu

Chengdu University of Traditional Chinese Med

792151883@qq.com15182728386

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Aug 10, 2026