PCOS
Conditions
Interventions
Untreated PCOS:No intervention measures
The PCOS group after electroacupuncture treatment:No intervention measures
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Healthy control group (HC) 1) Age 18-40 years old, female; 2) BMI 18.5-28.0 kg/m², matched with the PCOS group; 3) Regular menstrual cycle (21-35 days), without menstrual disorders, amenorrhea, etc.; 4) No clinical manifestations of hyperandrogenism (such as hirsutism, acne, seborrheic dermatitis, etc.); 5) No organic diseases of endocrine, metabolism, nervous system, heart, liver, kidney, etc. in the past 3 months; 6) No use of any drugs affecting nerves, endocrine, metabolism in the past 3 months; 7) Able to complete rs-fMRI examination during the menstrual period/follicular phase; 8) Voluntarily signed informed consent form and able to cooperate with all research tests and evaluations. Untreated PCOS patient group 1) Age 18-40 years old, female; 2) Met the Rotterdam PCOS diagnostic criteria in 2003 (satisfying 2 out of the following 3 items, and excluding other diseases causing hyperandrogenism and ovulation disorders): oligoovulation or no ovulation; clinical or biochemical hyperandrogenic manifestations; pelvic ultrasound indicating polycystic ovarian changes; 3) At least 3 months without any treatment for PCOS, including electroacupuncture, acupuncture, oral contraceptives, progestogens, ovulation-promoting drugs, traditional Chinese medicine, etc.; 4) Able to complete rs-fMRI examination during the menstrual period/follicular phase; 5) Voluntarily signed informed consent form and able to cooperate with all research tests and evaluations. Electroacupuncture treatment group for PCOS patients (PCOS + EA) 1) Age 18-40 years old, female, meeting the above PCOS diagnostic criteria; 2) Completed at least 24 standardized electroacupuncture treatments, with the treatment plan being unified: select classic acupoints such as Guanyuan, Zhongji, Sanyinjiao, Zusanli, Taiyang, etc., using sparse-dense waves (2/100 Hz), with the current intensity determined by the subject's tolerance, at least 2 treatments per week, each 20-30 minutes; 3) Electroacupuncture treatment compliance = 80% (actual treatment times / planned treatment times = 80%); 4) No combination of other treatments for PCOS during the treatment period; 4) Able to complete rs-fMRI examination during the menstrual period/follicular phase; 5) Voluntarily signed informed consent form and able to cooperate with all research tests and evaluations.
Exclusion criteria
Exclusion criteria: 1) Those with severe organic diseases of the heart, liver, kidney, cerebrovascular system, blood system, etc.; 2) Those with severe mental disorders such as schizophrenia, bipolar disorder, severe anxiety and depression; 3) Those with a history of central nervous system diseases such as brain trauma, epilepsy, brain tumor, multiple sclerosis, etc.; 4) Those with contraindications for rs-fMRI testing (such as having metal implants in the body, pacemakers, claustrophobia, etc.) or unable to cooperate in completing brain function testing; 5) Pregnant or lactating women, or those with a planned pregnancy within the last 3 months; 6) Those who have used drugs affecting neurotransmitters and hormone levels within the last 3 months, such as glucocorticoids, antipsychotics, antidepressants, contraceptives, etc.; 7) Those with a history of drug abuse, alcoholism, or smoking (smoking = 5 cigarettes per day, drinking = 3 times per week); 8) Those who cannot complete rs-fMRI testing during the menstrual period/follicular phase; 9) Those who refuse to sign the informed consent form, or those who cannot cooperate in completing the research assessment due to cognitive or communication disorders; 10) Those who have participated in other clinical trials within the last 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain function indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical parameters;Psychological state indicators; | — |
Countries
China
Contacts
Public ContactGui Juan
Renmin Hospital of Wuhan University
Outcome results
None listed