coronary heart disease with depression
Conditions
Interventions
Electroacupuncture group:Acupuncture was performed on both bilateral Neiguan and Shenmen acupoints. The electro-acupuncture machine was connected (with a frequency range of 4Hz to 20Hz and an initial
Control group:No acupuncture intervention was carried out
only the natural course of the disease was observed.
Sponsors
Beijing University of Chinese Medicine Dongzhimen Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Meets the diagnostic criteria for stable coronary heart disease; (2) Meets the diagnostic criteria for mild to moderate depression; (3) Has not taken any psychotropic drugs, and has no severe complications or acute diseases; (4) No gender restrictions, aged 40-70 years old, with well-controlled blood pressure and blood sugar (blood pressure controlled within 90-140 mmHg/60-90 mmHg, random blood sugar controlled within 3.9-11.1 mmol/L); (5) Left ventricular ejection fraction > 50%; (6) Has no contraindications for acupuncture and has signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Those with severe depression who need to take oral antidepressants, with a HAMD-24 score > 35; (2) Patients with aortic dissection aneurysm, rheumatic heart disease, primary cardiomyopathy and other non-coronary heart diseases; (3) Patients with severe pulmonary, liver, kidney dysfunction and primary diseases such as hematological disorders, or patients with severe cardiac dysfunction (NYHA Class I); (4) Those who have suffered from acute myocardial infarction, stroke and coronary artery PCI within the last month; (5) Pregnant or lactating women or women of childbearing age who have not taken effective contraceptive measures; (6) Patients in the terminal stage of malignant tumors with cachexia; (7) Patients with specific bleeding history, or bleeding history caused by taking warfarin; (8) Subjects with active infections; (9) Those who have received acupuncture treatment within the last month; (10) Those whose therapeutic effect cannot be determined or whose data are incomplete due to various reasons; (11) Those who are currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seattle Angina Scale;Hamilton Depression Scale;Depression Self-Rating Scale;Scan and observe changes in brain function (parameters such as low-frequency amplitude, local consistency, functional connectivity, etc.);cerebral blood flow;Analyze the integrity of white matter (various anisotropy scores such as FA, mean diffusivity MD, axial diffusivity AD, and radial diffusivity RD);Voxel-based brain morphometric measurement method; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index (PSQI);Multidimensional Fatigue Scale (MFI-20);Montreal Cognitive Assessment Scale (MoCa);Analysis of Heart Rate Variability; | — |
Countries
China
Contacts
Public ContactZhengguang Chen
Beijing University of Chinese Medicine Dongzhimen Hospital
Outcome results
None listed