Major Depressive Disorder
Conditions
Interventions
JPJY group:JPJY plus low?dose SSRI(20 mg/d) for 8 weeks
Control group:placebo plus standard?dose SSRI (50 mg/d) for 8 weeks
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for a major depressive episode as defined in the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-V). (2) Meet the diagnostic criteria for depression with childhood trauma: Hamilton Depression Rating Scale-17 (HDRS-17) score = 17; have a history of childhood trauma and a Childhood Trauma Questionnaire (CTQ-SF) score above the cut-off value. (3) TCM syndrome differentiation: Liver depression and spleen deficiency syndrome: mental depression, chest and rib distension, excessive suspicion and worry, frequent sighing, poor appetite, weight loss, feeling tired after slight activity, fullness and belching in the epigastrium, loose or dry stools, or discomfort in the throat; thin white tongue coating, taut and thin or taut and slippery pulse. (5) No gender restrictions, age 18-60 years old; (6) No severe heart, liver, or kidney diseases, no organic brain diseases, no history of tumors, blood diseases, rheumatism, malnutrition, or neurodegenerative diseases; (7) No history of tobacco, alcohol, or other psychoactive substance abuse; (8) Provide informed consent.
Exclusion criteria
Exclusion criteria: (1) Have severe heart, liver or kidney diseases; have brain organic diseases; have severe cardiovascular diseases, tumors, blood diseases history, rheumatism, malnutrition and neurological degeneration and other diseases; depressive episodes secondary to other mental disorders or physical diseases; (2) Have a history of tobacco, alcohol and other psychoactive substance abuse; (3) Pregnant women;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale,HAMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chinese Medicine Symptom Scale; | — |
Countries
China
Contacts
Public ContactLanying Liu
Shanghai Mental Health Center
Outcome results
None listed