Non-ST-elevation acute myocardial infarction and ischemic cardiomyopathy
Conditions
Interventions
Experimental group:Conventional Western medical therapy plus Suxiao Jiuxin Pill
Ultra–low-dose control group:Conventional Western medical therapy plus a placebo of Suxiao Jiuxin Pill
Sponsors
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria of non-ST-segment elevation acute myocardial infarction :1) to meet the diagnostic criteria of non-ST-segment elevation acute myocardial infarction; 2) The time from onset to enrollment was within 3 weeks ; 3) No thrombolysis or interventional therapy was performed according to the routine diagnosis and treatment, condition or patient 's wishes before enrollment. 4) 4 18 years old = age = 80. 2. Inclusion criteria of ischemic cardiomyopathy:1) Conform to the diagnostic criteria of ischemic cardiomyopathy ; 2) NYHA grade II-IV ; 3) patients who need to be hospitalized due to decompensated heart failure ; 4) 18 years old = age = 80.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria of non-ST-segment elevation acute myocardial infarction: 1) Acute ST segment elevation myocardial infarction, 2) combined with acute heart failure, acute myocarditis, pericardial disease, valvular heart disease, congenital heart disease, dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy and other diseases, 3) There was a history of persistent supraventricular tachycardia or bradycardia, 4) combined with systemic diseases, tumors, thyroid or parathyroid dysfunction and other endocrine diseases, 5) acute and chronic lung diseases, pulmonary heart disease, 6) with severe infection, moderate or severe liver and kidney dysfunction, active cerebrovascular disease, blood system diseases, 7) there is a history of exposure to cardiotoxic substances, such as cardiotoxic anti-tumor drugs, antidepressants, heavy metals, and inappropriate excessive radiation exposure. 2. Exclusion criteria of ischemic cardiomyopathy: 1) The main causes of heart failure were primary valvular heart disease, rheumatic heart disease, congenital heart disease, hypertrophic cardiomyopathy, pulmonary heart disease, hypertensive heart disease, pericardial disease, arrhythmogenic cardiomyopathy, drug (radiotherapy, chemotherapy drugs, etc. ) induced heart disease, immune system associated cardiomyopathy, constrictive pericarditis, stress heart disease, ventricular septal perforation, papillary muscle rupture or dysfunction, 2) acute myocardial infarction, cardiogenic shock, 3) combined with uncontrollable thyroid disease, malignant tumor, immune system disease, leukemia, lymphoma, etc, 4) severe liver dysfunction or severe renal dysfunction, 5) pregnant or lactating women ; 6) Left ventricular assist device was implanted or heart transplantation was performed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall response rate (ORR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac ultrasonographic parameters;24-hour dynamic heart rate;High-sensitivity C-reactive protein, Complete Blood Count, Comprehensive serum biochemical panel, Serum neurotransmitter levels (epinephrine, acetylcholine, dopamine, serotonin, etc.), Serum nerve growth factor; | — |
Countries
China
Contacts
Public ContactFan Guanwei
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed