PCOS
Conditions
Interventions
Group A (Lifestyle Interventions):Receive basic lifestyle interventions (in accordance with the 2023 International Evidence-Based Guidelines for PCOS), under the guidance of trained researchers or nut
Group B (lifestyle interventions + Tiaojing Yulu Decoction oral solution):Undergo basic lifestyle interventions: take 1 dose per day, divided into 2 servings, starting from the first day of menstruati
Group C (Lifestyle intervention + Metformin Hydrochloride Tablets):Undergo basic lifestyle interventions. Initial dose: 0.5 g per dose, once daily (taken with dinner)
for 1 week.
Group D (lifestyle intervention + Tiaojing Yulu Decoction oral solution + Metformin Hydrochloride tablets):Participants received basic lifestyle interventions. They took medications in the same manner
Sponsors
Liuzhou Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Ages 20–40 years; meeting the diagnostic criteria of both Western and traditional Chinese medicine; have not used hormonal medications, metformin, ovulation-stimulating drugs, or traditional Chinese medicine treatments in the past 3 months; willing to sign the informed consent form.
Exclusion criteria
Exclusion criteria: Hyperandrogenemia due to other causes; thyroid dysfunction; severe cardiac, hepatic, or renal insufficiency (ALT/AST >2.5 times the upper limit of normal, Cr >115 µmol/L); diabetes mellitus (fasting blood glucose =7.0 mmol/L or use of hypoglycemic medications); mental illness or cognitive impairment; participation in other clinical trials at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rates of normalization of menstrual cycles;follicular fluid non-targeted metabolomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| rates of ovulation rates;luteinizing hormone;Insulin resistance index;ALT;rates ofpregnancy rates; testosterone;follicle-stimulating hormone; estradiol;traditional Chinese medicine syndrome scores;blood lipid levels; body mass index; waist circumference;AST; Cr; BUN;blood tests; urine tests; electrocardiogram;adverse events;targeted metabolomics;correlation networks; ROC prediction models; | — |
Countries
China
Contacts
Public ContactJING JING LI
Liuzhou Maternal and Child Health Hospital
Outcome results
None listed