Stroke
Conditions
Interventions
Experimental group:verum Xingnao Kaiqiao acupuncture
Control Group:sham Xingnao Kaiqiao acupuncture
Sponsors
Nanjing Medical University Affiliated Hospital No.1
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients with a first-ever stroke confirmed by CT or MRI (ischemic or hemorrhagic stroke, with lesions located in the cerebral hemisphere, brainstem, or cerebellum), with unilateral upper limb motor dysfunction as one of the main clinical manifestations. Time since stroke onset of approximately 2 weeks to 6 months, with a stable clinical condition and no evidence of progressive deterioration. Marked motor impairment of the paretic upper limb, with an FMA-UE score of approximately 20–50, and the ability to perform seated forward-reaching tasks on a tabletop or assisted active/isometric force tasks. Right-handed patients, predominantly with a unilateral lesion, aged approximately 40–80 years. Clear consciousness, ability to understand and follow instructions, and generally preserved cognitive function (e.g., MMSE =24). No severe cardiopulmonary insufficiency and able to tolerate approximately 40–60 minutes of acupuncture and fNIRS+sEMG assessment. Written informed consent provided by the participant or the participant's legally authorized representative.
Exclusion criteria
Exclusion criteria: A history of previous stroke or recurrent stroke. Bilateral or multiple large lesions resulting in severe involvement of both upper limbs, or severe ataxia/trunk balance impairment precluding stable completion of the assessment in a seated position. Other neurological disorders significantly affecting upper limb motor function, or severe joint contracture of the paretic upper limb, recent unhealed fracture or surgery, or severe pain that prevents task completion. Severe aphasia, marked disturbance of consciousness, severe cognitive impairment, or psychiatric symptoms that preclude effective cooperation. A high risk of bleeding (e.g., marked coagulation dysfunction or strong anticoagulation that cannot be adequately adjusted), or skin infection/severe dermatologic disease at the acupuncture or electrode placement sites, making acupuncture or electrode application unsafe. Severe systemic diseases, such as unstable angina, recent acute myocardial infarction, severe arrhythmia, or poorly controlled hypertension, or poor compliance preventing completion of the full assessment protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain-Muscle Coupling Change Amount;Changes in Blood Oxygen Dynamics in the Motor Cortex;The changes in electromyographic activity of the target muscle groups in the upper limb.; | — |
Countries
China
Contacts
Public ContactGuangxu Xu
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital)
Outcome results
None listed