subthreshold depression
Conditions
Interventions
Electroacupuncture Group Combined with Psychological Therapy Group:Electroacupuncture group combined with psychotherapy
The micro-electroacupuncture group combined with the psychotherapy group.:Micro-electro acupuncture group combined with psychological therapy
Psychotherapy Team:Psychotherapy
Sponsors
Shenzhen City Luohu District Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
13 Years to 18 Years
Inclusion criteria
Inclusion criteria: Experimental group: (1) Age: 13–18 years; (2) Meeting the clinical diagnostic criteria for subthreshold depression, with a HAMD-7 score between 7 and 17; (3) First-episode, drug-naïve patients, or no history of antidepressant treatment within the past year; (4) Right-handed; (5) Signed informed consent obtained from guardians and the participant. Healthy control group: (1) Age: 13–18 years; (2) Right-handed; (3) No current or past history of psychiatric disorders based on detailed evaluation, Patient Health Questionnaire-9 (PHQ-9) total score < 5, and all item scores = 1; (4) Snaith-Hamilton Pleasure Scale (SHAPS) total score within the normal range, with no significant anhedonia; (5) Signed informed consent obtained from guardians and the participant.
Exclusion criteria
Exclusion criteria: Experimental Group: (1) Any history of psychiatric disorders; (2) History of neurological diseases or brain injury; (3) History of major or chronic physical illnesses that have received systematic treatment; (4) Use of psychotropic medications (e.g., antidepressants, anxiolytics, sedative-hypnotics) within the recent 3 months prior to enrollment; (5) Any contraindication to MRI scanning (e.g., metal implants in the body, pacemaker, claustrophobia, etc.); (6) Intellectual disability (assessed by school performance or clinical impression; individuals suspected of intellectual impairment must undergo the Wechsler Intelligence Scale, and those with IQ < 80 are excluded); (7) Any other factor that, in the investigator's judgment, makes the individual unsuitable for the study. Healthy Control Group: (1) History of psychiatric disorders or family history, including but not limited to depressive disorder, anxiety disorder, obsessive-compulsive disorder, schizophrenia, substance use disorder, etc.; presence of any clinically significant psychological symptoms; or a first-degree relative (parents, full siblings) with a confirmed family history of psychiatric disorders (especially mood disorders);(2) Neurological and physical illnesses: a definite history of neurological diseases (e.g., epilepsy, traumatic brain injury with loss of consciousness, encephalitis, etc.); serious or unstable physical illnesses (e.g., endocrine diseases, autoimmune diseases, cardiovascular diseases, hepatic or renal insufficiency, etc.); (3) Any contraindication to MRI scanning; (4) Medication use: long-term use of any psychotropic medications within the recent 3 months prior to enrollment; history of substance abuse or dependence (including alcohol, tobacco, illicit drugs); (5) Other factors: intellectual disability (individuals with IQ < 80 are excluded); (6) Experience of a major negative life event within the recent 6 months prior to enrollment (e.g., death of a loved one, parental divorce, etc.) that caused severe psychological impact; (7) Any other factor that, in the investigator's judgment, makes the individual unsuitable for the study. Individuals meeting any of the above criteria are not eligible for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale;MRI Data; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Pittsburgh Sleep Quality Index; | — |
Countries
China
Contacts
Public ContactYu Xin
Shenzhen City Luohu District Traditional Chinese Medicine Hospital
Outcome results
None listed