Severe viral pneumonia
Conditions
Interventions
Control group:Conventional Western medical treatments include drug therapy (antiviral drugs, antibiotics, corticosteroids, etc.) and mechanical ventilation support when necessary. On this basis, Wenya
Treatment group:Conventional Western medical treatments include drug therapy (antiviral drugs, antibiotics, corticosteroids, etc.) and mechanical ventilation support when necessary. On this basis, Wen
Sponsors
Guangdong Provincial Hospital of Chinese Medicine Dade Road General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) It meets the above diagnostic criteria for severe viral pneumonia and is diagnosed as a syndrome of Yang deficiency and toxin invasion in traditional Chinese medicine. (2) 18 to 85 years old, gender not limited; (3) The onset time is =12 days (or the time from the first symptom appearance or the time from the positive nucleic acid/antigen test to randomization does not exceed 12 days); (4) Within 72 hours of a clear diagnosis of severe viral pneumonia; (5) The subject or his/her legal representative signs the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Expected to die within 24 hours; (2) Extracorporeal membrane oxygenation (ECMO) or invasive mechanical ventilation for =48 hours is required; (3) Weight less than 40kg, or body mass index (BMI) =35 kg/m²; (4) Suffering from active pulmonary tuberculosis or incurable malignant tumors (Clinical cure of tumors is defined as: after treatment, the patient's symptoms and signs disappear, and the tumor cannot be found in the re-examination of imaging for more than 5 years.) Or severe primary diseases of the hematopoietic system (leukemia, myelodysplastic syndrome, idiopathic thrombocytopenia, etc.); (5) Received treatment with traditional Chinese medicine prescriptions for warming Yang and detoxifying based on syndrome differentiation for more than 3 days before enrollment; (6) Those who have a history of allergy to the components of the tested traditional Chinese medicine; (7) Pregnant women or patients who are breastfeeding; (8) Those who are currently participating in clinical trials of other drugs or have participated in other clinical trials within one month; (9) Subjects who are judged by the researcher as unsuitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The improvement rate of clinical status on the 14th day; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality;Length of hospital stay;Length of stay in the ICU;The number of non-mechanical ventilation days within 28 days;The improvement rate of clinical status on the 7th day;PSI score;SOFA scoring;Changes in the oxygenation index of peripheral capillaries; | — |
Countries
China
Contacts
Public ContactXi Xiaotu
Guangdong Provincial Hospital of Chinese Medicine Dade Road General Hospital
Outcome results
None listed