Acute Exacerbation of Chronic Obstructive Pulmonary Disease During the Peri-Discharge Period
Conditions
Interventions
Experimental group:Basic treatment with Guben Kechuan granule
Control group:Basic treatment with Placebo
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1: a. Meet the diagnostic criteria for Chronic Obstructive Pulmonary Disease (COPD), with lung function classified as Grade II-IV (Groups B and E), be in the peri-discharge period of Acute Exacerbation of COPD (AECOPD), and conform to the Traditional Chinese Medicine (TCM) syndrome of spleen deficiency with excessive phlegm and insecure kidney qi 2: b. Aged 40–75 years, regardless of gender 3: c. Inpatients 4: d. No prior use of Guben Kechuan Granules 5: e. Be willing to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1: a. Patients with airflow limitation caused by other respiratory diseases such as bronchial asthma, bronchiectasis, pulmonary tuberculosis, and lung cancer 2: b. Patients with severe concurrent diseases of the heart, brain, liver, kidney, etc., who are unable to cooperate with exercise 3: c. Patients with impaired immune systems or those receiving long-term immunosuppressive therapy 4: d. Patients currently participating in another interventional clinical trial of drugs or medical devices.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of improvement in Forced Expiratory Volume in 1 second (FEV1); | — |
Secondary
| Measure | Time frame |
|---|---|
| COPD Assessment Test (CAT) Questionnaire;St. George's Respiratory Questionnaire (SGRQ) score;Modified Medical Research Council (mMRC) Dyspnea Questionnaire;6-Minute Walk Test (6MWT);C-reactive protein;WBC;T-lymphocyte;Indicators of inflammation;Transcriptome assays;Detection of serum metabolic profile;Lipidomic detection; | — |
Countries
China
Contacts
Public ContactFeng Cuiling
Peking University People's Hospital
Outcome results
None listed