Chronic obstructive pulmonary disease
Conditions
Interventions
Experimental group:Gexian decoction
Control group:Budesonide and Formoterol Inhalation
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) Age at onset > 40 years old 2) Persistent respiratory symptoms 3) Symptoms vary in severity, but most of the time, symptoms and exertional dyspnea are present 4) Chronic cough and expectoration occur before dyspnea and are unrelated to triggering factors 5) Persistent airflow limitation (FEV1/FVC < 70% after inhaling bronchodilator) 6) Persistent abnormal lung function during stable phase 7) Previous diagnosis of COPD, chronic bronchitis, or emphysema 8) Severe exposure to risk factors: tobacco smoke, biofuels, etc 9) Symptoms progress slowly over time 10) Rapid-acting bronchodilators can only provide limited symptom relief 11) Chest imaging suggests severe hyperinflation If there are more than 3 diagnoses, it is diagnosed as COPD.
Exclusion criteria
Exclusion criteria: (1) Those who do not meet the inclusion criteria; (2) Individuals who are allergic to the test drug or its components; (3) Those who are in the exacerbation phase of the disease and require hospitalization or systemic hormone therapy; (4) Those who are unable to cooperate in completing the necessary examinations related to pulmonary function and this trial; (5) Patients suffering from malignant tumors or major hematological diseases; (6) Patients with concomitant respiratory failure, active tuberculosis, pulmonary heart disease, or other respiratory system-related diseases; (7) Patients with severe cardiac, hepatic, renal dysfunction, or central nervous system diseases; (8) Female subjects who are pregnant, breastfeeding, or planning to become pregnant; (9) Individuals with a history of alcohol dependence, mental disorders, or documented substance abuse behavior; If any of the above criteria are met, the participant cannot enter the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mMRC questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| symptom score;syndrome score; | — |
Countries
China
Contacts
Public ContactXueqin Hu
The First Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed