Anticancer targeted drugs-related skin side effects
Conditions
Interventions
Trial group:Taohong Siwu Decoction plus urea ointment
Control group:placebo plus urea ointment
Sponsors
Fangshan Hospital Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
15 Years to 85 Years
Inclusion criteria
Inclusion criteria: (a) Patients pathologically diagnosed malignant tumor are treated by angiogenesis inhibitors, which belong to syndrome of wind-dryness due to blood deficiency; (b) age from 18 to 85 years old; (c) no severe organic dysfunction and auto-immune diseases; (d) patients understand the study and sign consent form.
Exclusion criteria
Exclusion criteria: (a) patients have other skin diseases or systemic disease with skin lesions; (b) patients are experiencing treatment for hand-foot skin reaction; (c) patients are predicted to discontinue anti-angiogenesis targeted drugs in 2 weeks; (d) antibiotics have been used within the past 3 months; (e) Terpenoid compounds such as carotenoids, camphor, rosin acids, menthol, borneol, or vitamin A were applied to the affected skin lesions in the past 7 days; (f) patients with allergic constitution; (g) Severe skin ulceration with concurrent infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain assessment;Scope of skin lesion;Quality of life assessment;Dermoscopy evaluation;Analysis of skin microbiome;Safety evaluation; | — |
Countries
China
Contacts
Public ContactPENG Yanmei
Fangshan Hospital Beijing University of Chinese Medicine
Outcome results
None listed