Olanzapine-induced hyperglycemia
Conditions
Interventions
Intervention Group:Mogroside 100 mL per sachet, 3 times daily, 1 sachet each time, for 8 weeks
follow-up for another 8 weeks
Waiting-list Group:Follow-up for 8 weeks
then Mogroside 100 mL per sachet, 3 times daily, 1 sachet each time, for 8 weeks
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Meets the diagnostic criteria for schizophrenia according to the International Classification of Diseases, 10th Revision (ICD-10); (2) Fixed dose of olanzapine for at least 1 month; (3) Fasting blood glucose =6.1 mmol/L and not on any antidiabetic medications; (4) Age between 45-65 years, both genders; (5) Provides written informed consent to participate in this study.
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women; (2) Severe somatic diseases; (3) Currently using drugs such as clozapine, SSRIs, or SNRIs that increase the risk of hyperglycemia; (4) Other conditions affecting blood sugar or currently using antidiabetic medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting Blood Glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Height;Body-weight;blood lipids;HBA1c;Liver functions;16S rDNA sequencing;Gastrointestinal motility; | — |
Countries
China
Contacts
Public ContactChao Luo
Shanghai Mental Health Center
Outcome results
None listed