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fMRI Study on the Therapeutic Efficacy and Central Mechanisms of Tuina for Primary Dysmenorrhea with the Cold Congestion and Blood Stasis Pattern

fMRI Study on the Therapeutic Efficacy and Central Mechanisms of Tuina for Primary Dysmenorrhea with the Cold Congestion and Blood Stasis Pattern

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026001387
Enrollment
Unknown
Registered
2026-05-26
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary Dysmenorrhea

Interventions

Experimental Group:Tuina
Control Group:Oral Ibuprofen

Sponsors

Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 30 Years

Inclusion criteria

Inclusion criteria: 1) Nulliparous women aged 15 to 30 years with primary dysmenorrhea (PD);2) Meeting the Western medical diagnostic criteria for primary dysmenorrhea;3) Conforming to the TCM diagnostic criteria for dysmenorrhea of the cold congelation and blood stasis pattern;4) Having a regular menstrual cycle (28±7 days);5) No organic pelvic lesions identified by pelvic examination, pelvic ultrasonography or laparoscopy;6) Suffering from persistent menstrual pain with a Visual Analogue Scale (VAS) score of =4;7) No analgesics taken within 24 hours prior to magnetic resonance imaging (MRI) scanning, no analgesics, sedatives or hormonal drugs administered within one week before treatment, and no oral contraceptives used within three months;8) Voluntarily participating in the clinical study and providing signed informed consent.

Exclusion criteria

Exclusion criteria: 1) Diagnosed with secondary dysmenorrhea or dysmenorrhea induced by intrauterine device (IUD) use;2) Pregnant or preconception women;3) A history of cardiovascular and cerebrovascular diseases or psychiatric disorders;4) With contraindications to functional magnetic resonance imaging (fMRI) scans;5) Hypersensitive to ibuprofen sustained-release capsules or with a history of severe adverse reactions to the drug;6) Alcohol or drug dependence.

Design outcomes

Primary

MeasureTime frame
Visual Analogue Scale;—

Secondary

MeasureTime frame
Cox Menstrual Symptom Scale;Pittsburgh Sleep Quality Index;Brain Magnetic Resonance Imaging;Self-Rating Anxiety Scale;Self-Rating Depression Scale;TCM Syndrome Score;—

Countries

China

Contacts

Public ContactZhiGangLin

Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine

1027721244@qq.com18506051546

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Jun 11, 2026