viral pneumonia
Conditions
Interventions
Control group of viral pneumonia complicated with metabolic syndrome:Treat with Western medicine in accordance with the guideline standards
Experimental Group of Viral Pneumonia complicated with metabolic syndrome:Treat with Western medicine in accordance with the guideline standards and take Huopu Xialing Decoction orally
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1)Age: 18-75 years old, gender not limited; 2)All participants must meet the diagnostic criteria for viral pneumonia. Participants in the metabolic disorder syndrome group must also meet the diagnostic criteria for metabolic syndrome in this condition before they can be enrolled; 3) Onset time less than 7 days; 4) Agree to collect blood, BALF and fecal samples and sign a written informed consent form; 5) Be able to abide by the follow-up and sample collection procedures; 6) Possess language communication skills and be capable of independently filling out questionnaires or cooperating to complete research-related evaluations.
Exclusion criteria
Exclusion criteria: 1) There are the following severe conditions of heart, lung, liver and kidney insufficiency: a) Respiratory failure; Severe pneumonia b) Underlying pulmonary diseases: 1. Having a history of hospitalization due to the onset of chronic obstructive pulmonary disease within the past year; 2. Asthma with wheezing attacks; 3. Interstitial lung diseases such as rapidly progressive interstitial lung disease (RPILD) 4. Connective tissue disease-related interstitial lung disease (CTD-ILD); c) Liver dysfunction: The Child-Pugh score for liver function is below grade B; d) Renal insufficiency: Creatinine clearance rate < 30ml/min; e) Cardiac insufficiency: There are severe heart diseases, such as acute heart failure, fatal arrhythmias, etc., and the patient is unable to tolerate treatment intervention or sample collection during the research process (such as blood sampling, BALF collection). 2) Patients with active malignant tumors who need maintenance chemotherapy, radiotherapy or immunotherapy. 3) Patients with concurrent autoimmune diseases who are currently receiving immunosuppressant treatment, such as rheumatoid arthritis, systemic lupus erythematosus, vasculitis, undifferentiated connective tissue diseases, systemic sclerosis, etc. 4) Pregnant and lactating women. 5) Patients who have used systemic glucocorticoids within the past month. 6) Patients with cognitive impairments, including those in the active stage of schizophrenia and the acute stage of Alzheimer's disease, who are unable to understand and cooperate with the research process. 7) At the time of screening, any one of the infectious disease screening indicators meets the following standards: a) Positive for hepatitis B virus surface antigen (HBsAg); b) Positive for HCV antibody and HCV-RNA; c) Positive for Treponema pallidum antibody (Anti-TP) (If the Treponema pallidum serological test is positive, a non-Treponema pallidum serological test will be further conducted. The latter is negative and the patient who was determined by the researcher to have been infected with syphilis in the past but has been cured meets the inclusion criteria); d) Human Immunodeficiency Virus Antibody (Anti-HIV) 8) There was a long-term history of alcohol abuse or drug use within 12 months prior to enrollment. 9) Patients who had active pulmonary tuberculosis within 12 months prior to enrollment. 10) Those who were judged by the researchers as unsuitable for inclusion in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severe case rate;Metabolomics differences; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time required for the fever to subside;Blood lactic acid, pyruvate, the radio of blood lactic acid and pyruvate;Serum inflammatory factors;Length of stay;Clinical pulmonary infection score; | — |
Countries
China
Contacts
Public ContactXu Yinji
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed