Knee osteoarthritis
Conditions
Interventions
Control Group:Diacerein Capsules
Sponsors
Fujian University of Traditional Chinese Medicine Affiliated Third People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meets the diagnostic criteria for KOA; (2) Meets the criteria for TCM syndrome differentiation; (3) Unilateral KOA with radiographic X-ray K-L grading: Grade II-III, accompanied by joint space narrowing, subchondral bone cystic changes, or sclerosis; (4) Age between 50 and 75 years, gender unrestricted; (5) No KOA-related treatment within the past 3 months, including oral medications, intra-articular drug injections, or non-drug therapies; (6) Patients willing to accept and actively cooperate with this study, and sign the informed consent form for clinical research.
Exclusion criteria
Exclusion criteria: (1) Patients with a history of knee joint trauma and other secondary KOA; (2) Patients with failure of important organs such as heart, liver, and kidneys; (3) Patients with malignant tumors or benign tumors in the knee joint area; (4) Patients with rheumatoid arthritis, ankylosing spondylitis, gout, metabolic bone diseases, or other severe conditions; (5) Patients with a history of knee joint surgery; (6) Patients with cognitive impairments or mental illnesses; (7) Women in lactation or pregnancy; (8) Patients unsuitable for MRI examination; (9) Patients allergic to the drugs or components used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transverse relaxation time;Whole-Organ Magnetic Resonance Imaging Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index ;Visual Analog Scale;Aggrecan;Matrix Metallopeptidase 13;Osteoprotegerin;Receptor Activator of Nuclear Factor-? B Ligand;Beclin1;Microtubule-associated protein 1 light chain 3; | — |
Countries
China
Contacts
Public ContactChen Peng
Fujian University of Traditional Chinese Medicine Affiliated Third People's Hospital
Outcome results
None listed