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Mechanistic Study of Jianpi Yishen Xiezhuo Formula in Attenuating Acute Kidney Injury-to-Chronic Kidney Disease Transition through LTBP4-Mediated Inhibition of DRP1-Dependent Mitochondrial Dysfunction

Mechanistic Study of Jianpi Yishen Xiezhuo Formula in Attenuating Acute Kidney Injury-to-Chronic Kidney Disease Transition through LTBP4-Mediated Inhibition of DRP1-Dependent Mitochondrial Dysfunction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2026001300
Enrollment
Unknown
Registered
2026-05-26
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The progression of acute kidney injury to chronic kidney disease

Interventions

Chronic Kidney Disease Group:No intervention, only observation.
Acute Kidney Injury Group:No intervention, only observation.
Healthy Control Group:No intervention, only observation.

Sponsors

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Diagnosis criteria for the diseases: 1. AKI (Acute Kidney Injury) diagnosis criteria are based on the KDIGO 2012 guidelines. 2. CKD (Chronic Kidney Disease) diagnosis criteria are based on the KDIGO 2024 guidelines. 3. Or healthy individuals.

Exclusion criteria

Exclusion criteria: Suspected mental health issues leading to communication difficulties, unable to follow the research protocol or sign the informed consent form.

Design outcomes

Primary

MeasureTime frame
Latent Transforming Growth Factor Beta Binding Protein 4;—

Countries

China

Contacts

Public ContactLijialin

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University

lijialin3689@163.com13051167829

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Jun 11, 2026