Colorectal cancer
Conditions
Interventions
Control Group:Routine care
Experimental Group:Wrist-ankle acupuncture therapy once daily, 30 minutes per session, 5 times weekly (subjects blinded to needle retention). Acupoint selection based on "Wrist-Ankle Acupuncture Thera
Sponsors
Wuhan Fourth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Colorectal cancer patients receiving oxaliplatin chemotherapy (FOLFOX regimen) postoperatively (chemotherapy cycle =3 months); Patients with = grade 2 peripheral neurotoxicity (NCI-CTCAE score) after chemotherapy; Predominantly sensory abnormalities (numbness, tingling), excluding severe neuropathy primarily manifesting as motor dysfunction. Age 18-75 years, excluding pediatric and elderly patients (due to physiological differences that may affect efficacy evaluation). Signed informed consent, voluntary participation in the study, and compliance with follow-up
Exclusion criteria
Exclusion criteria: Comorbid with other neuropathies (e.g., diabetic neuropathy, herpes zoster neuropathy, alcoholic neuropathy, hereditary neuropathy); Previous acupuncture treatment, Chinese herbal medicine, or other neuroprotective agents (e.g., alpha-lipoic acid); Coagulation disorders, local skin infections, or mental illnesses preventing compliance with assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| National Cancer Institute Common Terminology Criteria for Adverse Events Version 5.0;Numerical Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30;TCM Syndrome Score; | — |
Countries
China
Contacts
Public ContactZhang Minqin
Wuhan Fourth Hospital
Outcome results
None listed