Knee osteoarthritis
Conditions
Interventions
Treatment group:Five-step Knee Manipulation
Healthy volunteer:Non-intervention
Sponsors
Shanghai Municipal Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1)Meet the diagnostic criteria for knee osteoarthritis (KOA) as specified in the 2010 "Guidelines for the Diagnosis and Treatment of Osteoarthritis" by the Rheumatology Branch of the Chinese Medical Association. 2)X-ray examination demonstrating Kellgren-Lawrence grade II or III osteoarthritis (K-L grade 0: normal; grade I: no narrowing of joint space, suspicious osteophytes or a small amount of osteophytes; grade II: suspicious narrowing of joint space, with evident osteophytes; grade III: significantly narrowed joint space, mild sclerotic changes in bone, and moderate osteophyte formation; grade IV: severely narrowed joint space, severe sclerotic changes, and obvious joint deformity, with numerous osteophytes). 3)Age between 40 and 70 years, inclusive, for both males and females. 4)Visual Analog Scale (VAS) score for knee osteoarthritis joint pain = 3 points and = 8 points (score range: 0-10 points). 5)Willingness to provide informed consent and complete the research protocol as outlined.
Exclusion criteria
Exclusion criteria: 1)Patients with previous knee surgery. 2)Patients with acute inflammation or infection around the knee joint. 3)Pregnant women. 4)Patients with tumors, infections, immune system-related diseases, or poorly controlled diabetes, hypertension, and heart disease. 5)Patients who took anticoagulants, steroids, immunosuppressants, or other drugs within 3 months before treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale, VAS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index, WOMAC;Range Of Motion, ROM;15 meters fast-paced walk time;Lower limb alignment;Cross Sectional Area, CSA;Gait Analysis;Adverse Event; | — |
Countries
China
Contacts
Public ContactXiaofeng Li
Shanghai Municipal Hospital of Traditional Chinese Medicine
Outcome results
None listed