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Investigation of the Application and Mechanism of Anti-Itch Wash in Perianal Eczema Based on the NF-?Bp65 Pathway

Investigation of the Application and Mechanism of Anti-Itch Wash in Perianal Eczema Based on the NF-?Bp65 Pathway

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026001245
Enrollment
Unknown
Registered
2026-05-15
Start date
2025-02-17
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perianal eczema

Interventions

High concentration of traditional Chinese medicine group (20%):Mix the anti-itch lotion with warm water in a 1:4 ratio to make a diluted solution.
Medium concentration group of traditional Chinese medicine (10%):Mix the anti-itch lotion with warm water in a 1:9 ratio to make a diluted solution.
Low concentration of traditional Chinese medicine group (5%):Mix the anti-itch lotion with warm water in a 1:19 ratio to make a diluted solution.
Control group:Compound Huangbai liquid

Sponsors

Yinchuan Traditional Chinese Medicine Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1) Aged between 18 and 65 years, male or female; 2) Meeting the diagnostic criteria for perianal eczema; 3) Meeting the traditional Chinese medicine diagnostic criteria for perianal eczema of the Damp-Heat in Lower Energizer pattern; 4) No use of relevant medications (including Chinese and Western medicines) within the past two weeks; 5) Agreement to participate in this trial and voluntarily signing the informed consent form.

Exclusion criteria

Exclusion criteria: 1) Women who are pregnant, planning to become pregnant, or breastfeeding; 2) Individuals with an allergic constitution or known allergy to the medications to be used in this trial; 3) Patients with severe primary diseases involving the liver, kidney, or hematopoietic system, as well as those with mental disorders; 4) Use of medications related to the treatment of eczema (such as Chinese herbal medicine, Chinese patent medicine, topical or oral antihistamines, etc.) within the past 4 weeks;

Design outcomes

Primary

MeasureTime frame
Perianal itch points;Rash morphology integral;Integral area of skin lesions;

Secondary

MeasureTime frame
TNFa IL6;

Countries

China

Contacts

Public ContactFanXianXian

Yinchuan Traditional Chinese Medicine Hospital

3374240232@qq.com+86 13895481796

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Jun 11, 2026