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Study on the Role and Mechanism of Lingnan Flying Needle Therapy in Regulating the SWELL1-NMDAR-BDNF Axis to Promote Neural Repair and Motor Function Reconstruction after Stroke

Study on the Role and Mechanism of Lingnan Flying Needle Therapy in Regulating the SWELL1-NMDAR-BDNF Axis to Promote Neural Repair and Motor Function Reconstruction after Stroke

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026001241
Enrollment
Unknown
Registered
2026-05-15
Start date
2026-02-14
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke

Interventions

Control group (sham acupuncture group):On the basis of conventional treatment, sham acupuncture was administered, with the same acupoints as the treatment group. Disposable sterile placebo needles and
Treatment group (Lingnan Feizhen Therapy Scalp Acupuncture Group):On the basis of conventional treatment, Lingnan Feizhen Therapy scalp acupuncture is added. Nine acupoints in the Jueyin area are sele

Sponsors

Guangdong Second Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients in the convalescent phase of ischemic stroke with onset ranging from 14 to 90 days; aged between 30 and 70 years; conscious with stable vital signs, and capable of cooperating with treatment and assessment; scoring 5 to 20 on the National Institutes of Health Stroke Scale (NIHSS), and with a pre-stroke modified Rankin Scale (mRS) score of no more than 1; and those who have voluntarily signed the informed consent form.

Exclusion criteria

Exclusion criteria: Patients with neurological deficits caused by non-ischemic etiologies such as hemorrhagic stroke, brain tumor, and brain trauma; patients with severe organ dysfunction, contraindications to acupuncture and moxibustion, and contraindications to MRI examination; patients with severe cognitive impairment, aphasia, and mental illness who are unable to cooperate; pregnant or lactating women; and patients who participate in other clinical interventions at the same time.

Design outcomes

Primary

MeasureTime frame
Simplified Fugl-Meyer Assessment;

Secondary

MeasureTime frame
Modified Rankin Scale (MRS);Modified Ashworth scale;Modified Barthel Index;Traditional Chinese Medicine Symptom Score;

Countries

China

Contacts

Public ContactLi Min

Guangdong Second Hospital of Traditional Chinese Medicine

309926016@qq.com138221598985

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Jun 11, 2026