Pulpitis
Conditions
Interventions
Experimental group:Receive standardized pulpotomy treatment combined with oral Liuwei Dihuang Pills intervention.
Control group:Receive standardized pulpotomy treatment combined with oral placebo intervention.
Sponsors
Stomatological Hospital Affiliated to Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18 years or older, regardless of gender; 2) Moderate or severe pulpitis (Wolters classification) with intraoperative pulp hemostasis time = 10 minutes; percussion test (_) or (±), no obvious tooth mobility; 3) Periapical tissues shown normal on X-ray films or PAI = 2; 4) No root fracture, cracked tooth, or prior endodontic treatment history; 5) Restorable tooth defect with favorable coronal sealing achievable after treatment.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of prior endodontic treatment or dental trauma; 2) Patients with obvious periapical lesions, periapical cysts or apical periodontitis (PAI = 3), and combined periodontal-endodontic lesions on X-ray films; 3) Cases of initial pulpitis, mild pulpitis, pulp necrosis, unrestorable teeth, and vertical root fracture; 4) Patients complicated with severe systemic diseases, such as severe cardiac, hepatic or renal insufficiency, and immune system diseases; 5) Patients with poorly controlled diabetes mellitus (HbA1c > 7%); pregnant or lactating women; 6) Patients allergic to any ingredient of Liuwei Dihuang Pills.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Matrix Metalloproteinase-9;Interleukin-6;Transforming Growth Factor-ß1; | — |
Countries
China
Contacts
Public ContactZheng Pei
Stomatological Hospital Affiliated to Zhejiang Chinese Medical University
Outcome results
None listed