Sepsis induced by Intra-abdominal Infection
Conditions
Interventions
Exposome: Syndrome of Internal Blockage by Static Blood and Toxin:Conventional sepsis treatment + Xuebijing, 100 ml per administration, twice daily, for 5 days
Non-exposome Group: Other TCM Syndrome Types:Conventional sepsis treatment + Xuebijing, 100 ml per administration, twice daily, for 5 days
Sponsors
Beijing Friendship Hospital,Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1: Age = 18 years 2: Meets the Sepsis 3.0 diagnostic criteria 3: Sequential Organ Failure Assessment score of 2–14 points 4: Intra-abdominal infection 5: The traditional Chinese medicine (TCM) syndrome types include stasis-toxin internal retention, toxic heat internal exuberance, fu-qi obstruction, qi-yin exhaustion, and yang qi sudden collapse 6: Sign the informed consent form
Exclusion criteria
Exclusion criteria: 1: Patients with a diagnosis of sepsis for more than 48 hours were included. 2: Pregnant or lactating women 3: severe primary disease affecting survival. 4: continuous use of immunosuppressants within the past 6 months, or organ transplant recipients. 5: participation in another clinical trial within 30 days. 6: Acute Physiology And Chronic Health Evaluation II score = 30 7: Allergy to any component of Xuebijing or allergic constitution
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sequential Organ Failure Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein (CRP) ;bilirubin;TCM symptom score ;procalcitonin;Disseminated Intravascular Coagulation Score;28-day mortality rate ;activated partial thromboplastin time ;fibrinogen;length of hospital stay (LOS) ;oxygenation index ;international normalized ratio;Acute Physiology And Chronic Health Evaluation II;D-Dimer;prothrombin time;creatinine ;platelet;Duration of Mechanical Ventilation;Intensive Care Unit length of stay;Etiological examination; | — |
Countries
china
Contacts
Public ContactQi Wenjie
Beijing Friendship Hospital,Capital Medical University
Outcome results
None listed