Colorectal adenoma
Conditions
Interventions
Experimental group:Take the modified Astragalus and Softshell Turtle Decoction Granules once a day, 1 bag each time, and take it by dissolving in water.
Control group:Take the modified Astragalus and Softshell Turtle Decoction Comfort Granules once a day, 1 bag each time, and take it by dissolving in water.
Sponsors
Shanghai Putuo District Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) After the polyp removal surgery under colonoscopy, the age range is 18 to 75 years old; (2) The pathological diagnosis is: tubular adenoma, tubulovillous adenoma, villous adenoma, and serrated adenoma; (3) The TCM syndrome type is consistent with spleen deficiency with blood stasis syndrome; (4) The diet is relatively stable, not a vegetarian, able to complete the questionnaire, and voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with familial adenomatous polyposis, PJ syndrome, inflammatory bowel disease, etc. as indicated by colonoscopy; (2) Regular use of COX-2 inhibitors, NSAIDs, calcium supplements, Vitamin D, probiotics, etc. medications; (3) Patients who have undergone partial or total gastrectomy or local resection of the colon and rectum, and are intolerant to colonoscopy; (4) Patients with severe diseases such as heart, brain, lung, liver, kidney, nervous system, hematopoietic system or malignant tumors; (5) Abnormal liver and kidney function, defined as: creatinine > 1.5 times the upper limit of normal (ULN), and/or AST, fourteen Shanghai Pu Zhou District Health System Scientific and Technological Innovation Project Plan Task Sheet (2026 Edition) ALT > 2.0×ULN, and/or total bilirubin > 1.5×ULN; (6) The subject has an allergic constitution or is known to be allergic to the ingredients of the test medication; (7) Pregnant women, lactating women, and patients with mental disorders; (8) Patients with a BOSTON intestinal preparation score of = 7 points, and those whose colonoscopy withdrawal time is = 6 minutes; (9) Subjects who have taken antibiotics or probiotics in the past 3 months before the test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the abundance and diversity of gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recurrent rate, recurrence rate; 8/5000 Pathological nature of colon polyps;Traditional Chinese Medicine Syndrome Score;Gastrointestinal symptom score; | — |
Countries
China
Contacts
Public ContactDai Xiaoling
Shanghai Putuo District Traditional Chinese Medicine Hospital
Outcome results
None listed