acute pancreatitis
Conditions
Interventions
Control group:Standard treatment
Experimental group:Standard treatment combined with modified Dachaihu Decoction for enema therapy.
Sponsors
Run Run Shaw Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1: Any 2 of the following 3 criteria: persistent pain in the upper abdomen (acute, severe onset, radiating back); 2) Serum amylase and (or) lipase were 3 times higher than the upper limit of normal; 3) Imaging examination (CT, MRI, or B-ultrasound) showed pancreatic enlargement, exudation, or necrosis. 2: Patients diagnosed as fu-organ heat junction syndrome, at least meet the following 2 main disease +1 tongue and pulse or 1 main disease +2 secondary disease +1 tongue and pulse. The main symptoms include: 1) full abdominal hard pain and refusal to press; 2) Dry stool. Secondary symptoms include: 1) diurnal hot flushes; 2) Vomiting; 3) Bad breath; 4) Short red urine. Tongue pulse: 1) the tongue is red, the fur is yellow, thick and greasy or dry; 2) Large or slippery pulse. 3: 18 -75 years old (including boundary values). 4: Admission within 72 hours of onset. 5: Volunteer to participate in the study and sign the informed consent. If the subject is unable to read and sign the informed consent due to incapacity or other reasons, its guardian is required to represent the informed process and sign the informed consent. If the subject does not have the ability to read the informed consent form (e.g., illiterate subjects), a witness is required to witness the informed process and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1: Acute pancreatitis in pregnancy. 2: Chronic pancreatitis or pancreatitis associated with pancreatic tumors. 3: Patients who have undergone surgical drainage and debridement and need emergency ERCP treatment. 4: A history of severe cardiovascular, respiratory, kidney, liver, hematological, malignant, or immune diseases. 5: Some vulnerable groups, such as mental disorders, cognitive dysfunction. 6: The investigator considered it inappropriate to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory indicators and related scores;Total score of TCM syndromes;Intestinal flora;Complications: occurrence of duodenal fistula, organ dysfunction, etc;Length of stay (treatment cycle);Total cost of treatment;The conversion rate of moderate and severe pancreatic inflammation; | — |
Countries
China
Contacts
Public ContactHong Yu
Run Run Shaw Hospital, Zhejiang University School of Medicine
Outcome results
None listed