Diminished Ovarian Reserve
Conditions
Interventions
experimental group:Gui Shen Yi Jing Granules plus Coenzyme Q10 placebo
control group:Coenzyme Q10 plus Gui Shen Yi Jing Granules placebo
Sponsors
Dongzhimen Hospital, Beijing University of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
25 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) fulfillment of the diagnostic criteria for diminished ovarian reserve; (2) fulfillment of the Traditional Chinese Medicine pattern differentiation criteria for kidney deficiency syndrome; (3) age between 25 and 45 years (25 = age < 45); (4) baseline follicle-stimulating hormone level between 10 and 25 IU/L (10 IU/L = baseline FSH < 25 IU/L); and (5) voluntary provision of written informed consent after being fully informed of the study details.
Exclusion criteria
Exclusion criteria: (1) pregnancy or lactation; (2) comorbidities involving severe conditions of the cardiovascular, cerebrovascular, or hematopoietic systems, or malignant tumors; (3) primary amenorrhea or a family history of early menopause; (4) diminished ovarian reserve caused by ovarian or related surgery; (5) mental disorders or intellectual disability; (6) use of hormonal medications within the past 3 months; or (7) concurrent participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Basal serum Follicle-Stimulating Hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| Basal serum luteinizing hormone;Follicle-Stimulating Hormone/Luteinizing Hormone;estradiol;anti-Müllerian hormone;Basal antral follicle count;Scoring of Traditional Chinese Medicine Syndromes;Modified Kupperman score; | — |
Countries
China
Contacts
Public ContactYun Shi
Dongzhimen Hospital, Beijing University of Chinese Medicine
Outcome results
None listed