Varicocele-associated heat stress male infertility disease
Conditions
Interventions
Intervention Group (Epimedium Group):The experimental group adopted the principle of postoperative basic treatment combined with Epimedium extract intervention. Patients who met the diagnostic criteri
Control Group:Select patients with the same clinical profile as the intervention group, who after undergoing microsurgical varicocelectomy, are administered an equivalent amount of placebo for 30 cons
Sponsors
Nanjing Medical University the Second Affiliated Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Meets the diagnostic criteria for varicocele according to Western medicine; (2) Meets the diagnostic criteria for kidney deficiency and blood stasis syndrome according to Traditional Chinese Medicine (TCM); (3) Sperm concentration: 1×10^6/ml = sperm concentration <15×10^6/ml or 1% = PR <32%; (4) Patient age: 18 years = age =60 years; (5) Voluntarily participates in this clinical trial and signs the written informed consent form.
Exclusion criteria
Exclusion criteria: (1) Congenital obstructive azoospermia, genital malformations, secondary varicocele, including nutcracker syndrome, and varicocele caused by compression from abdominal or retroperitoneal tumors; (2) Patients with severe oligozoospermia and severe asthenozoospermia; Criteria: Sperm concentration <1×10^6/mL, sperm progressive motility (PR) <1%; (3) Patients who have taken medications related to the treatment of this disease, specifically kidney-nourishing and sperm-generating drugs, within the past month; (4) Patients with severe underlying primary diseases of the heart, liver, kidneys, or other systems, or mental disorders; (5) Patients with known allergies to any components of the investigational drug; (6) Patients who have participated in other clinical trials within the past three months prior to randomization; (7) Patients deemed unsuitable for participation in this clinical trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sperm concentration;sperm forward motility;testicular volume;Semen Biochemical Analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale;Sperm DNA Fragmentation Rate;Maximum diameter of the spermatic vein (under Color Doppler Flow Imaging) during Valsalva maneuver.; | — |
Countries
China
Contacts
Public ContactDeng Zhonglei
Department of Urology, the Second Affiliated Hospital of Nanjing Medical University.
Outcome results
None listed