Lumbar Disc Herniation and Osteoporosis
Conditions
Interventions
Control Group:Diclofenac Sodium Enteric-coated Sustained-release Capsules, Methylcobalamin Tablets, Calcium Carbonate D3 Tablets (II)
Observation group:Combined use of Henggu bone injury healing agent on the basis of the control group.
Sponsors
Hunan Provincial Research Institute of Traditional Chinese Medicine Affiliated Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meets the diagnostic criteria for diseases related to LDH and OP as well as Chinese medicine syndrome; (2) Patients seeking treatment for LDH-related illness (new onset or recurrence); (3) Age between 55 and 75 years; (4) No use of NSAIDs or anti-osteoporosis medications within the past month; (5) Voluntarily participates and signs the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with severe underlying diseases such as heart, brain, liver, kidney, or tumor conditions; (2) Patients with diseases affecting bone metabolism, such as thyroid diseases, diabetes, or rheumatoid arthritis; (3) Patients undergoing surgery for lumbar disc herniation or osteoporotic fractures; (4) Patients allergic to the study medication; (5) Patients with poor compliance; (6) Patients who withdraw from the study due to severe adverse reactions or other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum bone turnover markers:(osteocalcin, OC) (procollagen type 1 C-peptide, P1NP) (ß cross-linked C-telopeptide of type 1 collagen, ß-CTX); | — |
Secondary
| Measure | Time frame |
|---|---|
| numeric rating scales, NRS;Roland Morris Questionnaire,RMQ;Functional Status in Activities of Daily Living;Serum inflammatory factor expression levels:(tumor necrosis factor-a, TNF-a) (interleukin, IL-17) (prostaglandin E2, PGE2) ;Safety observation: Blood routine examination and liver and kidney function indicators were tested before and after treatment.; | — |
Countries
China
Contacts
Public ContactKuang Jianjun
Hunan Province Institute of Traditional Chinese Medicine
Outcome results
None listed