dry age-related macular degeneration
Conditions
Interventions
Experimental group:Qihuang Granules were prepared at a dosage of 10 g per bag, composed of Fructus Lycii, Fructus Broussonetiae, Fructus Leonuri, Radix Salviae Miltiorrhizae, Radix Platycodonis, Radix
Control group:Lutein tablets (specification: 10 mg of lutein per tablet) were administered orally at a dosage of one tablet once daily for a continuous treatment period of 3 months.
Sponsors
Guangdong Second Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1: Age: 50–79 years, regardless of gender 2: Meet the diagnostic criteria of dry AMD 3: Meet the TCM syndrome criteria of liver-kidney yin deficiency and phlegm-stasis interminglement for dry AMD. 4: Patients without prior anti-VEGF, laser or surgical treatment 5: Patients with good compliance who can cooperate with ophthalmic examinations, complete standardized treatment, voluntarily provide clinical data, and provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1: With concurrent wet AMD, diabetic retinopathy, glaucoma or other vision-affecting ocular fundus diseases 2: Received anti-VEGF drugs, glucocorticoids, immunosuppressants or other Chinese medicines for AMD within the recent 3 months. 3: Abnormal hepatic and renal function: ALT/AST > 1.5 × ULN, serum creatinine > ULN 4: Allergy to Qihuang Granules or lutein. 5: Not conforming to the TCM syndrome pattern of Liver-Kidney Yin Deficiency combined with Phlegm-Stasis Interminglement. 6: Those with cognitive impairment, mental illness, or other conditions that prevent them from cooperating in follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best-corrected visual acuity;Amsler grid;NEI VFQ-25;Multi-spatial frequency contrast sensitivity function;Drusen volume;Retinal vascular flow density;Choroidal blood flow density and thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of the inflammatory cytokines IL-1ß, IL-18;Serum levels of the inflammatory cytokines NLRP3;Hemorheological parameters; | — |
Countries
China
Contacts
Public ContactWangyan
Guangdong Second Traditional Chinese Medicine Hospital
Outcome results
None listed