Cough Variant Asthma (Wind-Prevailing and Tendon-Cramping Syndrome)
Conditions
Interventions
Traditional Chinese Medicine Treatment Group:Jingchan Cough-Relief Granules + conventional Western medical treatment
Western Medicine Treatment Group:Routine Western medical treatment
Sponsors
Panjin City Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Meets the Western medical diagnostic criteria for cough variant asthma (CVA): (a) Clinical symptoms: Paroxysmal cough lasting more than 8 weeks, without wheezing or dyspnea. (b) Auscultation of both lungs reveals no wheezing. (c) Pulmonary function tests: Mostly normal, with a positive bronchial provocation test. (d) Ineffective with antibiotics and antitussive drugs, but effective with ß2 receptor agonists, theophylline, and other bronchodilators, as well as glucocorticoids. (e) Cough often occurs at night and can be triggered by inhaling cold air (smoke, volatile irritants, etc.) or physical activity. (f) The patient has a history of allergic diseases or a family history of such conditions, or a history of upper respiratory tract infections. (2) Chinese medical pattern identification: Wind pathogen with spasmodic constriction (cough, or paroxysmal choking cough, dyspnea, itching in the throat, sudden onset or exacerbation triggered by cold air or odors, or severe cough upon waking in the morning, recurrent episodes, dry cough without phlegm or minimal phlegm, thin white coating on the tongue, floating, tight, or taut pulse). (3) Age between 18 and 65 years.
Exclusion criteria
Exclusion criteria: 1. Known allergy to any of the drugs used in this study (Jingchan Zhike Formula herbal medicine, budesonide, salmeterol/fluticasone, montelukast, etc.) or their excipients. 2. Pregnant or breastfeeding women, or those planning to become pregnant during the study period or within 1 month after its completion. 3. Presence of other known chronic cough etiologies requiring specific treatment, such as gastroesophageal reflux disease (GERD) or upper airway cough syndrome (UACS) (postnasal drip). 4. Concurrent acute respiratory tract infections at screening (e.g., acute pharyngitis, tonsillitis, pneumonia, etc.). 5. Concurrent severe respiratory diseases, such as chronic obstructive pulmonary disease (COPD), bronchiectasis, lung cancer, active tuberculosis, or interstitial lung disease. 6. Concurrent severe primary diseases of the cardiovascular, hepatic, renal, or hematologic systems, or mental disorders, which, in the investigator's judgment, may affect the safety of the trial or the integrity of the data. 7. Participation in any other clinical trial of drugs or medical devices within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TCM Syndrome Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary Function Test; | — |
Countries
China
Contacts
Public ContactLiu Ying
Panjin City Traditional Chinese Medicine Hospital
Outcome results
None listed