Subthreshold depression
Conditions
Interventions
Ganmai Dazao decoction group:On the basis of health education, patients were administered Jiawei Ganmai Dazao Decoction.
Placebo group:On the basis of health education, placebo granules were administered.
Sponsors
Fujian University of Traditional Chinese Medicine, College of Rehabilitation
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Age 18–60 years, gender unrestricted; 2) Score of 16–25 on the Center for Epidemiologic Studies Depression Scale (CES-D); 3) Right-handed; 4) Signed informed consent and voluntary participation.
Exclusion criteria
Exclusion criteria: 1) Meet the diagnostic criteria for mood disorders, bipolar depressive disorder, psychosis, etc., according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); 2) Have a history of major depression, epilepsy or family history of epilepsy, neurodegenerative diseases, cerebrovascular diseases, neurological diseases, brain injury, etc.; 3) Have a history of using antipsychotic drugs or addictive disorders (e.g., drug abuse, alcoholism, etc.); 4) Have contraindications to magnetic resonance imaging (MRI) scanning, such as internal metal implants (e.g., cardiac pacemakers, cochlear implants, metal joints and other ferromagnetic foreign bodies), hyperthermia, pregnancy, claustrophobia, etc.; 5) Patients with severe sleep disorders or severe anxiety disorders: Insomnia Severity Index (ISI) score = 22, Hamilton Anxiety Rating Scale (HAMA) score = 29; 6) Participants currently enrolled in other clinical trials that may affect the evaluation of the present study results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HamiltonDepressionScale,HAMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| PatientHealthQuestionnaire, PHQ-9;Perceived Stress Scale, PSS;Chinese Affective Scale, CAS;Generalized Anxiety Disorder,GAD-7;12-items Short From Health Survey,SF-12;Brain structure and function; | — |
Countries
China
Contacts
Public ContactJingsong Wu
Fujian University of Traditional Chinese Medicine, College of Rehabilitation
Outcome results
None listed