Premature ovarian insufficiency
Conditions
Interventions
Acupuncture group:Acupuncture and Electroacupuncture
Sham acupuncture group:Sham acupuncture and sham electroacupuncture
Sponsors
The First Affiliated Hospital of Hunan University of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: Meet the diagnostic criteria for POI; be between 25 and 40 years of age and have regular menstrual cycles; have received no other treatment in the 2 months prior to enrollment; voluntarily agree to participate in this study and be able to actively cooperate with the study protocol; and sign an informed consent form. Participants who meet all five of the above criteria will be enrolled in the study.
Exclusion criteria
Exclusion criteria: Congenital abnormalities of the reproductive organs; patients with severe concomitant diseases of the cardiovascular, hepatic, renal, hematopoietic, or nervous and psychiatric systems, as well as conditions such as diabetes or hypertension; patients who have undergone unilateral or bilateral oophorectomy; patients who are unable to tolerate blood tests or ultrasound examinations during the study, or who are unable to complete acupuncture sessions or the full course of treatment; patients currently participating in other clinical trials; patients who refuse to sign the informed consent form. Any participant meeting any of the above criteria will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Follicle-stimulating hormone;estradiol;Luteinizing hormone;Anti-Müllerian hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of follicles;Modified Kupperman Score;Quality of Life Score for Perimenopausal Women;Anxiety Self-Rating Scale Score;Serum glutamate;Serum gamma-aminobutyric acid;Serum serotonin;Glutamate in the hypothalamus and pituitary gland;Gamma-aminobutyric acid in the hypothalamus and pituitary gland;Serotonin in the hypothalamus and pituitary gland; | — |
Countries
China
Contacts
Public ContactLiu Xiaojuan
The First Affiliated Hospital of Hunan University of Chinese Medicine
Outcome results
None listed