Major depressive disorder
Conditions
Interventions
Sponsors
Sichuan provincial BAYI rehabilitation center (Sichuan provincial rehabilitation hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. A current diagnosis of major depressive disorder based on DSM-V; 2. 18 to 60 years old; 3. Right-hander; 4. The score of the 24-item Hamilton Depression Rating Scale (HAMD-24) is greater than 8 and less than 35; 5. No contraindications to magnetic resonance imaging (e.g., metallic implants, claustrophobia); 6. Psychotropic drug-free-period of at least three months; 7. Voluntarily participating in the research and signing of the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe uncontrolled diseases, such as hypertension, diabetes, thyroid diseases, etc. 2. Patients with severe visceral diseases or malignant tumors. 3. Patients with other psychiatric disorders, such as bipolar disorder or schizophrenia. 4. Patients with cognitive impairment (Montreal cognitive assessment score <26). 5. Patients with suicidal behavior or plans. 6. Patients with diseases that affect intracranial vessels or tissues. 7. Pregnant or lactating women. 8. Patients currently participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale-24 items; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Pittsburgh Sleep Quality Index;Patient Health Questionnare;Indicators of functional magnetic resonance imaging;Indicators of structural magnetic resonance imaging; | — |
Countries
China
Contacts
Public ContactJuan Li
Chengdu University of Traditional Chinese Medicine
Outcome results
None listed