Adolescent Depression
Conditions
Interventions
Acupuncture group:Acupuncture at Baihui, Yintang, Zhongwan, Qihai, Tianshu, Neiguan, Zusanli, and Taichong
add Sanyinjiao for overthinking, Zhongfu for melancholy, and Xingjian for anger-related depression.
Sham acupuncture group:The acupoints, procedures, and treatment cycles are the same as above. Flat-head needles are used, and the needle devices are fixed to the acupoints with adhesive tape. The need
Sponsors
Second Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
10 Years to 24 Years
Inclusion criteria
Inclusion criteria: diagnostic criteria comply with the elements of the International Classification of Diseases, 10th Revision (ICD-10) in terms of clinical symptomatology (low mood, loss of interest and pleasure, fatigue or reduced vitality) and a duration of =2 weeks, and meet the screening criteria of the "Diagnostic and Statistical Manual of Mental Disorders" (5th edition) (DSM-5). The criteria for the diagnosis of Chinese medicine syndromes refer to the main symptoms of liver stagnation in the "Chinese Diagnosis and Treatment Plan for Depressive Disorders (2017 Edition)," accompanied by "thinking-related depression" - loss of appetite, weight loss, fatigue, and alternating loose and hard stools; "worry-related depression" - sadness, crying, chest oppression, and abdominal distension; and "anger-related depression" - irritability, chest and (costal region) distension, bitter taste in the mouth, and nausea. Depression group: Age between 10-24 years; meet the ICD-10 clinical symptomatology and have been screened through the DSM-5 diagnostic criteria, and refer to the Chinese medicine diagnostic criteria in the "Chinese Diagnosis and Treatment Plan for Depressive Disorders (2017 Edition)"; patients who have received antidepressant treatment must have a stable dose for at least 14 days prior to the visit; able to provide complete Chinese medicine (Four Diagnostic Methods) data, cooperate with relevant tests and examinations, etc.; good compliance, and voluntarily participate and sign the informed consent form. Healthy group: (1) Age between 10-24 years; no gender restrictions; (2) In good health, with no history of mental illness episodes, not diagnosed with depression or other mental disorders, and never taken any antidepressant medications; HAMD-24 =8; (3) Cooperate with relevant tests, etc.; good compliance and voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: The content does not meet the inclusion criteria; it involves somatic diseases, depressive symptoms induced by medications; severe mental disorders such as schizophrenia and bipolar affective disorders; organic mental disorders; malignant tumors and critical cardiovascular, cerebrovascular, hematological, and endocrine system diseases; abuse of alcohol or narcotics; cognitive dysfunction or abnormal mental status that prevents self-cooperation with the study; pregnant or breastfeeding women; diseases of thyroid or testicular function; participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale-24 ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh sleep quality index(PSQI);Epworth Sleepiness Scale (ESS);FS-14 Fatigue Scale;BDI-II;Sex hormones;Functional Magnetic Resonance Imaging (fMRI);Serum albumin;Peripheral Blood Neurotransmitters;Salivary BDNF promoter region methylation level;Changes in gut microbiota; | — |
Countries
China
Contacts
Public ContactLi Lihong
Second Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed