Decline in ovarian reserve function
Conditions
Interventions
Traditional Chinese medicine trial group:Jinfeng Pill + Fenmotone Analogue
control group:Fenmotone + Jinfeng Pill Mock
Sponsors
Obstetrics & Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) Females aged 18-45 years (2) Meet the DOR diagnostic criteria (at least 2 of the following): 1) Basal FSH =10 < 25 IU/L for at least two menstrual cycles (day 2~4 of the menstrual cycle) 2)AMH <1.1 ng/mL 3) AFC (antral follicle count) < 5 (3) Traditional Chinese medicine syndrome differentiation is kidney essence deficiency syndrome (4) Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) History of ovarian surgery, radiotherapy or chemotherapy, or known chromosomal abnormalities (such as Turner syndrome). 2) Patients with severe underlying medical conditions (such as liver or kidney dysfunction, a history of thrombosis, breast cancer, or other contraindications to HRT). 3) Those who have taken hormonal medications or drugs that affect ovarian function within the past 3 months, except dydrogesterone tablets. 4) Pregnant or breastfeeding women. 5) Individuals who are allergic to the components of the study drug. 6) Patients who are also taking other medications intended to enhance ovarian reserve function, such as vitamin E or coenzyme Q10. 7) Patients with intellectual disabilities or mental health conditions. 8) Individuals who have other contraindications to the use of estrogen or who, in the judgment of the study investigators, are not suitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Follicle-stimulating hormone (Days 2 to 5 of the menstrual cycle); | — |
Secondary
| Measure | Time frame |
|---|---|
| anti-Müllerian hormone;antral follicle count((Days 2 to 5 of menstruation));Follicle-stimulating hormone/luteinizing hormone(Days 2 to 5 of menstruation);Estradiol;Volume of both ovaries;ovulation rate;pregnancy rate;Traditional Chinese Medicine syndrome scoring system;Kupperman score;Anxiety and Depression Scale;Menopause-Specific Quality of Life Questionnaire; | — |
Countries
China
Contacts
Public ContactCAO Qi
Obstetrics & Gynecology Hospital of Fudan University
Outcome results
None listed