Ischemic stroke
Conditions
Interventions
Control Group:Basic treatment and rehabilitation training
Acupuncture group:In addition to the control group, acupuncture was added.
Sponsors
Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1 Meets the diagnostic criteria for ischemic stroke as described above; 2 Age between 35-75 years, stable vital signs, gender (gender); 3 First episode, confirmed by cranial MRI or CT scan as primarily located in subcortical regions (e.g., internal capsule, basal ganglia, corona radiata), without involving extensive motor cortex; 4 Mainly characterized by unilateral limb impairment; time from onset to enrollment is 7–14 days (based on confirmed onset time or first imaging confirmation); stable vital signs, able to undergo standardized rehabilitation training and MRI examination; with significant neurological deficits (NIH Stroke Scale (NIHSS) score of 4-24 points); 5 Fugl-Meyer Assessment for Upper Extremity (FMA-UE) =55 points or Fugl-Meyer Assessment for Lower Extremity (FMA-LE) =25 points, and at least minimal voluntary movement ability in the affected upper or lower limb (FMA-UE =10 points or FMA-LE =10 points), able to complete 4 weeks of rehabilitation training and assessment; 6 Mini-Mental State Examination (MMSE) score =20 points, with basic cognitive understanding and execution ability, able to cooperate with training and assessment; 7 The subject signs an informed consent form; if the subject has limited capacity to sign, the legal representative or authorized representative signs in accordance with regulations, and the subject's consent or awareness is obtained as much as possible.
Exclusion criteria
Exclusion criteria: 1 Non-ischemic stroke-related diseases such as intracerebral hemorrhage, brain tumors, and central nervous system infections; 2 Patients rated as Grade 4 on the Modified Ashworth Scale (MAS); 3 Patients with severe dysfunction of major organs, such as heart, liver, or kidney failure; 4 Patients with severe cognitive impairment (MMSE < 20 points), affecting cooperation in assessment and intervention; 5 Patients with severe mental disorders, affecting compliance and assessment; 6 Patients with severe fear of acupuncture, unable to cooperate even after adequate explanation and adaptation training; 7 Patients with contraindications for acupuncture therapy (e.g., severe coagulation disorders, local skin infection at acupuncture sites); 8 Patients with cranial MRI showing hemorrhagic transformation or concurrent other active intracranial hemorrhages; 9 Patients with pre-randomization imaging assessment indicating complete structural disruption of key white matter fiber bundles related to the study; 10 Patients who received systematic acupuncture treatment within the past 2 weeks (=3 sessions per week or consecutive treatment); 11 Patients with contraindications for MRI examination (e.g., pacemakers, metal implants, claustrophobia); 12 Patients with diabetes mellitus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Motor Functional Assessment Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale (NIHSS);Modified Barthel Index;1H-MRS Metabolite Ratios;DTI parameter;Fiber Tractography; | — |
Countries
China
Contacts
Public ContactWang Linlin
Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine
Outcome results
None listed