Psoriasis
Conditions
Interventions
Corosolic Acid Treatment Group:2% Corosolic Acid Cream applied twice daily to lesions for 8 weeks, with 8-week follow-up, alongside baseline therapy.
Control Group:Daivonex (Calcipotriol Ointment, LEO Laboratories Limited
15g:0.75mg) applied twice daily to lesions for 8 weeks, with 8-week follow-up, alongside baseline therapy.
Sponsors
Shanghai University of Traditional Chinese Medicine Affiliated Yueyang Integrated Chinese and Western Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet Western clinical diagnostic criteria for plaque psoriasis; 2. BSA =10% (lesions primarily located on trunk and/or limbs, excluding palms/soles, face/scalp, and genital areas); 3. Aged 18-75 years, any gender; 4. Willing to participate and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. History of intolerance to topical vitamin D3 derivatives or herbal topical treatments; 2. Other active skin diseases that may interfere with assessment; 3. Previous use of biologics (etanercept =14d, infliximab =40d, ixekizumab =52d, adalimumab =64d, guselkumab =72d, ustekinumab =84d, secukinumab =108d) or JAK inhibitors =1 week; 4. Severe uncontrolled local/systemic infections; 5. Uncontrolled severe diseases (cardiovascular, respiratory, etc.) or abnormal lab values: ALT/AST >2×ULN; Cr >1.3×ULN; hematologic parameters below LLN; 6. Major surgery within 8 weeks or planned during study; 7. History of malignancy, immunodeficiency, hypersensitivity, or family tumor history; 8. Pregnancy/lactation; 9. Substance abuse history; 10. Other investigator-determined exclusions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of subjects with =50% improvement in Psoriasis Area and Severity Index (PASI) score from baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Psoriasis Body Surface Area;Physician's Global Assessment;Dermatological Quality of Life Index;Recurrence Assessment; | — |
Countries
China
Contacts
Public ContactZhou Mi
Shanghai University of Traditional Chinese Medicine Affiliated Yueyang Integrated Chinese and Western Medicine Hospital
Outcome results
None listed