Diminished Ovarian Reserve
Conditions
Interventions
Decreased Ovarian Reserve group:Give Chinese medicine
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
Female
Age
21 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) Those who meet the diagnostic criteria of the expert consensus on the clinical diagnosis and treatment of ovarian reserve (2022 version); (2) Females of childbearing age 21~45 years old; (3) The patient voluntarily underwent clinical observation and signed the informed consent form. The diagnostic criteria in this study were formulated with reference to the Obstetrics and Gynecology (9th Edition) and the Expert Consensus on the Clinical Diagnosis and Treatment of Hypoactive Ovarian Reserve (2022 Edition): (1) AMH 10 IU/L for 2 consecutive menstrual cycles of which (1)~(3) can be diagnosed if any one of them is satisfied.
Exclusion criteria
Exclusion criteria: (1) Those who do not meet the diagnostic criteria for inclusion; (2) Combined with serious internal diseases such as heart brain lung diseases or combined with psychiatric diseases and communication disorders; (3) Tumors of the reproductive system and congenital malformations of reproductive organs; (4) genetic factors; (5) Received other exogenous hormones Chinese medicines or proprietary Chinese medicines within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| From the first medication to after 2 menstrual cycles, changes from baseline in serum AMH levels;Pregnancy rate after the first use of medication for 2 menstrual cycles;From the first medication to after 2 menstrual cycles, IVF outcomes (number of oocytes retrieved, fertilization rate, usable embryo rate);Chinese medicine syndrome score from the first medication to after 2 menstrual cycles; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bilateral ovarian AFC after the first medication up to 2 menstrual cycles;From the first dose to after 2 menstrual cycles, serum baseline hormone levels (FSH, LH, E2, etc.); | — |
Countries
China
Contacts
Public ContactZhou Feifei
Zhejiang Provincial People's Hospital
Outcome results
None listed