Sepsis-induced Myopathy
Conditions
Interventions
SIM disease group:Observational study without intervention
Healthy Volunteers Group:Observational study without intervention
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for SIM patients: a. Age between 18 and 85 years old, b. Meeting the criteria of sepsis-3.0 (sepsis is defined as infection + SOFA score = 2 points within the first 24 hours), c. Meeting the diagnostic criteria of acute muscle atrophy, d. Patients or their first-degree relatives (or legal representatives) agree to transfer MR and sign a written informed consent document. Inclusion criteria for healthy volunteers: a. Age between 18 and 85 years old, b. Blood test results showing normal inflammatory indicators (white blood cell count, procalcitonin, C-reactive protein), c. Sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Confirmation of pregnancy or positive urine ß-HCG test; 2. Newly diagnosed primary neuromuscular disease upon admission; 3. Patients unable to complete RFCSA measurement due to leg amputation, pelvic/femoral fracture, or knee/hip arthroplasty; 4. Patients with metastatic tumor (PD) or undergoing chemotherapy; 5. Patients receiving long-term oral corticosteroid therapy; 6. Patients unable to walk independently or with the aid of a device prior to sepsis onset; 7. Patients who participated in any drug clinical trial within the past 6 months prior to screening examinations; 8. Patients deemed unsuitable to participate in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rectus Femoris Cross-sectional Area;Muscle MRI Scan;All-cause mortality in 28-day;All-cause mortality in 28-day;All-cause mortality in 1-year; | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic Data;Traditional Chinese Medicine Four Diagnostic Methods Materials;Medical Research Council-Sum Score;Duration of prone ventilation;SOFA Score;Infection-related results;Oxygen kinetic index;Duration of stay in the ICU;Duration of invasive/non-invasive mechanical ventilation; | — |
Countries
China
Contacts
Public ContactChen Wei-Tao
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed