Moderate Knee Osteoarthritis
Conditions
Interventions
Huangdi Internal Acupuncture Group:Huangdi Internal Acupuncture
Celecoxib Group:Celecoxib Capsules
Sponsors
Yantai Yuhuangding Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 45–75 years. 2. Meet clinical diagnostic criteria for knee osteoarthritis with Kellgren-Lawrence grade II or III. 3. Average resting pain VAS score =4 (0–10 scale) in the target knee during the past week before screening. 4. For bilateral KOA, the more painful knee is designated as the target knee. 5. Voluntarily participate and sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. Received intra-articular injections (corticosteroids, hyaluronic acid, platelet-rich plasma, etc.) in the target knee within the past 3 months. 2. History of knee surgery (including arthroscopy) on the target knee, or planned knee surgery within the next 6 months. 3. Secondary arthritis (e.g., rheumatoid arthritis, ankylosing spondylitis, acute gouty arthritis, infectious arthritis, etc.). 4. Severe cardiovascular, cerebrovascular, hepatic, or renal insufficiency, coagulation disorders, or psychiatric disorders. 5. Known allergy or contraindication to celecoxib (e.g., sulfonamide allergy) or to diclofenac sodium. 6. Pregnant, planning pregnancy, or breastfeeding. 7. Currently participating in another interventional clinical trial. 8. Have used any of the following drugs within the first 4 weeks of enrollment: long-acting opioid analgesics (such as morphine, hydrocodone, fentanyl, etc.), antidepressants (such as amitriptyline, duloxetine, etc.), anticonvulsants (such as gabapentin, pregabalin, etc.), or other central nervous system drugs that may significantly affect pain perception (as determined by the researcher); The use of acetaminophen (daily dose = 2g) as a temporary remedial medication is allowed, but it needs to be recorded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity;Joint function and symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Synovial inflammation of knee joint (ultrasound);Specific knee joint function;Quality of life;Patient's overall improvement impression;Use of corrective medications; | — |
Countries
China
Contacts
Public ContactZhang Jing
Yantai Yuhuangding Hospital
Outcome results
None listed